TY  - JOUR
AU  - Berghaus, Natalie
AU  - Hielscher, Thomas
AU  - Savran, Dilan
AU  - Schrimpf, Daniel
AU  - Maas, Sybren L N
AU  - Preusser, Matthias
AU  - Weller, Michael
AU  - Acker, Till
AU  - Herold-Mende, Christel
AU  - Wick, Wolfgang
AU  - von Deimling, Andreas
AU  - Sahm, Felix
TI  - Meningiomas: Sex-Specific Differences and Prognostic Implications of a Chromosome X Loss.
JO  - Neuro-Oncology
VL  - 27
IS  - 4
SN  - 1522-8517
CY  - Oxford
PB  - Oxford Univ. Press
M1  - DKFZ-2024-02330
SP  - 1019-1028
PY  - 2025
N1  - #EA:B300#LA:B300# / 2025 May 15;27(4):1019-1028
AB  - Meningiomas are the most common primary intracranial tumours in adults. Several studies proposed new stratification systems with a more accurate risk prediction than the WHO grading, e.g. based on methylation and copy number variations (CNVs). Yet, common shortcomings in these analyses are either a lack of stratification by sex of patients or excluding the gonososmes from CNV assessment.Within this study, DNA methylation array data from 7,424 meningioma samples as well as targeted sequencing, clinical annotations and morphology subtyping of 796 samples were examined for differences between females and males regarding mutations, methylation classes, copy number variations and histology.Meningiomas from females accounted for about 53 
KW  - Copy Number Variations (Other)
KW  - Meningioma (Other)
KW  - X chromosome (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:39535060
DO  - DOI:10.1093/neuonc/noae239
UR  - https://inrepo02.dkfz.de/record/294555
ER  -