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@ARTICLE{Berghaus:294555,
      author       = {N. Berghaus$^*$ and T. Hielscher$^*$ and D. Savran$^*$ and
                      D. Schrimpf$^*$ and S. L. N. Maas and M. Preusser and M.
                      Weller and T. Acker and C. Herold-Mende and W. Wick$^*$ and
                      A. von Deimling$^*$ and F. Sahm$^*$},
      title        = {{M}eningiomas: {S}ex-{S}pecific {D}ifferences and
                      {P}rognostic {I}mplications of a {C}hromosome {X} {L}oss.},
      journal      = {Neuro-Oncology},
      volume       = {27},
      number       = {4},
      issn         = {1522-8517},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {DKFZ-2024-02330},
      pages        = {1019-1028},
      year         = {2025},
      note         = {#EA:B300#LA:B300# / 2025 May 15;27(4):1019-1028},
      abstract     = {Meningiomas are the most common primary intracranial
                      tumours in adults. Several studies proposed new
                      stratification systems with a more accurate risk prediction
                      than the WHO grading, e.g. based on methylation and copy
                      number variations (CNVs). Yet, common shortcomings in these
                      analyses are either a lack of stratification by sex of
                      patients or excluding the gonososmes from CNV
                      assessment.Within this study, DNA methylation array data
                      from 7,424 meningioma samples as well as targeted
                      sequencing, clinical annotations and morphology subtyping of
                      796 samples were examined for differences between females
                      and males regarding mutations, methylation classes, copy
                      number variations and histology.Meningiomas from females
                      accounted for about 53 $\%$ of the malignant tumours and
                      present a loss of one X chromosome in 57 $\%$ of these
                      malignant cases. In the group of benign tumours, females
                      comprised about 75 $\%$ of the patients. Therein, a loss of
                      one X chromosome was detected in only about 10 $\%$ of the
                      cases but was associated with a significantly worse
                      progression free survival.Although genomic instability is a
                      common feature of malignant meningiomas, particularly loss
                      of the X chromosome in tumours of female patients in
                      otherwise histologically and molecularly low-risk tumours
                      confers higher risk. Hence, the gonosomal copy number status
                      can be leveraged for increased diagnostic accuracy.},
      keywords     = {Copy Number Variations (Other) / Meningioma (Other) / X
                      chromosome (Other)},
      cin          = {B300 / C060 / B320 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)B300-20160331 / I:(DE-He78)C060-20160331 /
                      I:(DE-He78)B320-20160331 / I:(DE-He78)HD01-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39535060},
      doi          = {10.1093/neuonc/noae239},
      url          = {https://inrepo02.dkfz.de/record/294555},
}