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@ARTICLE{Ippen:294558,
      author       = {F. Ippen$^*$ and T. Hielscher$^*$ and D. Friedel$^*$ and K.
                      Göbel$^*$ and D. Reuss$^*$ and C. Herold-Mende and S. Krieg
                      and A. von Deimling$^*$ and W. Wick$^*$ and F. Sahm$^*$ and
                      A. K. Suwala$^*$},
      title        = {{T}he prognostic impact of {CDKN}2{A}/{B} hemizygous
                      deletions in {IDH}-mutant glioma.},
      journal      = {Neuro-Oncology},
      volume       = {27},
      number       = {3},
      issn         = {1522-8517},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {DKFZ-2024-02333},
      pages        = {743-754},
      year         = {2025},
      note         = {#EA:B300#LA:B300# / 2025 Mar 7;27(3):743-754},
      abstract     = {Homozygous deletions of CDKN2A/B are known to predict poor
                      prognosis in gliomas, but the impact of hemizygous deletions
                      is less clear. This study aimed to evaluate the prognostic
                      significance of hemizygous CDKN2A/B deletions in IDH-mutant
                      low-grade astrocytomas and oligodendrogliomas.Tissue samples
                      diagnosed as astrocytoma, IDH-mutant and oligodendroglioma,
                      IDH-mutant, 1p/19q co-deleted CNS WHO grade 2 and 3 were
                      collected from the archives of the Institute of
                      Neuropathology in Heidelberg. DNA methylation analysis was
                      performed on formalin-fixed paraffin-embedded (FFPE)
                      samples. Evaluation of the CDKN2A/B locus was performed by
                      visual inspection of copy-number plots derived from
                      methylation-array data for each case. Hemizygous and
                      homozygous losses were assessed in relation to whole
                      chromosomal or larger segmental losses and gains in the
                      chromosomal profile. Survival probabilities were assessed
                      using the Kaplan-Meier method.A total of 334 low-grade
                      glioma cases were identified, including 173 astrocytomas and
                      161 oligodendrogliomas. Hemizygous deletions in CDKN2A/B
                      (37/173 in astrocytomas, 15/161 in oligodendrogliomas) did
                      not confer significantly worse survival outcomes compared to
                      CDKN2A/B wildtype cases in neither low grade astrocytoma
                      (log-rank p= 0.2556; HR 2.29, $95\%$ CI [0.76; 6.40], p=
                      0.135) nor oligodendroglioma (log-rank p= 0.2760; HR 0.17;
                      $95\%$ CI [0.01; 5.05]; p= 0.305), regardless of CNS WHO
                      grade, which was further demonstrated on a subgroup of
                      astrocytoma, IDH mutant CNS WHO 4 cases (log-rank p= 0.1680;
                      HR 4.55, $95\%$ CI [0.88; 24.51], p= 0.0689).Hemizygous
                      CDKN2A/B deletions do not significantly worsen OS or PFS in
                      IDH-mutant astrocytomas and oligodendrogliomas, CNS WHO
                      grade 2 and 3.},
      keywords     = {CDKN2A/B (Other) / IDH-mutant glioma (Other) / hemizygous
                      deletion (Other) / survival (Other)},
      cin          = {B300 / C060 / B320 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)B300-20160331 / I:(DE-He78)C060-20160331 /
                      I:(DE-He78)B320-20160331 / I:(DE-He78)HD01-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39530475},
      doi          = {10.1093/neuonc/noae238},
      url          = {https://inrepo02.dkfz.de/record/294558},
}