%0 Journal Article
%A Tauziède-Espariat, Arnault
%A Friker, Lea L
%A Nussbaumer, Gunther
%A Bison, Brigitte
%A Dangouloff-Ros, Volodia
%A Métais, Alice
%A Sumerauer, David
%A Zamecnik, Josef
%A Benesch, Martin
%A Perwein, Thomas
%A van Vuurden, Dannis
%A Wesseling, Pieter
%A La Madrid, Andrés Morales
%A Garrè, Maria Luisa
%A Antonelli, Manila
%A Giangaspero, Felice
%A Pietsch, Torsten
%A Sturm, Dominik
%A Jones, David T W
%A Pfister, Stefan M
%A Grabovska, Yura
%A Mackay, Alan
%A Jones, Chris
%A Grill, Jacques
%A Ajlil, Yassine
%A von Bueren, André O
%A Karremann, Michael
%A Hoffmann, Marion
%A Kramm, Christof M
%A Kwiecien, Robert
%A Castel, David
%A Gielen, Gerrit H
%A Varlet, Pascale
%T Diffuse pediatric high-grade glioma of methylation-based RTK2A and RTK2B subclasses present distinct radiological and histomolecular features including Gliomatosis cerebri phenotype.
%J Acta Neuropathologica Communications
%V 12
%N 1
%@ 2051-5960
%C London
%I Biomed Central
%M DKFZ-2024-02358
%P 176
%D 2024
%X Diffuse pediatric-type high-grade gliomas (pedHGG), H3- and IDH-wildtype, encompass three main DNA-methylation-based subtypes: pedHGG-MYCN, pedHGG-RTK1A/B/C, and pedHGG-RTK2A/B. Since their first description in 2017 tumors of pedHGG-RTK2A/B have not been comprehensively characterized and clinical correlates remain elusive. In a recent series of pedHGG with a Gliomatosis cerebri (GC) growth pattern, an increased incidence of pedHGG-RTK2A/B (n = 18) was observed. We added 14 epigenetically defined pedHGG-RTK2A/B tumors to this GC series and provided centrally reviewed radiological, histological, and molecular characterization. The final cohort of 32 pedHGG-RTK2A/B tumors consisted of 25 pedHGG-RTK2A (78
%K Humans
%K Child
%K Male
%K Female
%K Brain Neoplasms: genetics
%K Brain Neoplasms: pathology
%K Brain Neoplasms: diagnostic imaging
%K Adolescent
%K Child, Preschool
%K Neoplasms, Neuroepithelial: genetics
%K Neoplasms, Neuroepithelial: pathology
%K Neoplasms, Neuroepithelial: diagnostic imaging
%K DNA Methylation
%K Glioma: genetics
%K Glioma: pathology
%K Glioma: diagnostic imaging
%K Phenotype
%K Gliomatosis cerebri (Other)
%K Methylation (Other)
%K Pediatric high-grade glioma (Other)
%K RTK2A (Other)
%K RTK2B (Other)
%K Receptor tyrosine kinase (Other)
%K pedHGG (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:39558399
%2 pmc:PMC11575044
%R 10.1186/s40478-024-01881-1
%U https://inrepo02.dkfz.de/record/294583