TY - JOUR AU - Tauziède-Espariat, Arnault AU - Friker, Lea L AU - Nussbaumer, Gunther AU - Bison, Brigitte AU - Dangouloff-Ros, Volodia AU - Métais, Alice AU - Sumerauer, David AU - Zamecnik, Josef AU - Benesch, Martin AU - Perwein, Thomas AU - van Vuurden, Dannis AU - Wesseling, Pieter AU - La Madrid, Andrés Morales AU - Garrè, Maria Luisa AU - Antonelli, Manila AU - Giangaspero, Felice AU - Pietsch, Torsten AU - Sturm, Dominik AU - Jones, David T W AU - Pfister, Stefan M AU - Grabovska, Yura AU - Mackay, Alan AU - Jones, Chris AU - Grill, Jacques AU - Ajlil, Yassine AU - von Bueren, André O AU - Karremann, Michael AU - Hoffmann, Marion AU - Kramm, Christof M AU - Kwiecien, Robert AU - Castel, David AU - Gielen, Gerrit H AU - Varlet, Pascale TI - Diffuse pediatric high-grade glioma of methylation-based RTK2A and RTK2B subclasses present distinct radiological and histomolecular features including Gliomatosis cerebri phenotype. JO - Acta Neuropathologica Communications VL - 12 IS - 1 SN - 2051-5960 CY - London PB - Biomed Central M1 - DKFZ-2024-02358 SP - 176 PY - 2024 AB - Diffuse pediatric-type high-grade gliomas (pedHGG), H3- and IDH-wildtype, encompass three main DNA-methylation-based subtypes: pedHGG-MYCN, pedHGG-RTK1A/B/C, and pedHGG-RTK2A/B. Since their first description in 2017 tumors of pedHGG-RTK2A/B have not been comprehensively characterized and clinical correlates remain elusive. In a recent series of pedHGG with a Gliomatosis cerebri (GC) growth pattern, an increased incidence of pedHGG-RTK2A/B (n = 18) was observed. We added 14 epigenetically defined pedHGG-RTK2A/B tumors to this GC series and provided centrally reviewed radiological, histological, and molecular characterization. The final cohort of 32 pedHGG-RTK2A/B tumors consisted of 25 pedHGG-RTK2A (78 KW - Humans KW - Child KW - Male KW - Female KW - Brain Neoplasms: genetics KW - Brain Neoplasms: pathology KW - Brain Neoplasms: diagnostic imaging KW - Adolescent KW - Child, Preschool KW - Neoplasms, Neuroepithelial: genetics KW - Neoplasms, Neuroepithelial: pathology KW - Neoplasms, Neuroepithelial: diagnostic imaging KW - DNA Methylation KW - Glioma: genetics KW - Glioma: pathology KW - Glioma: diagnostic imaging KW - Phenotype KW - Gliomatosis cerebri (Other) KW - Methylation (Other) KW - Pediatric high-grade glioma (Other) KW - RTK2A (Other) KW - RTK2B (Other) KW - Receptor tyrosine kinase (Other) KW - pedHGG (Other) LB - PUB:(DE-HGF)16 C6 - pmid:39558399 C2 - pmc:PMC11575044 DO - DOI:10.1186/s40478-024-01881-1 UR - https://inrepo02.dkfz.de/record/294583 ER -