TY  - JOUR
AU  - Tauziède-Espariat, Arnault
AU  - Friker, Lea L
AU  - Nussbaumer, Gunther
AU  - Bison, Brigitte
AU  - Dangouloff-Ros, Volodia
AU  - Métais, Alice
AU  - Sumerauer, David
AU  - Zamecnik, Josef
AU  - Benesch, Martin
AU  - Perwein, Thomas
AU  - van Vuurden, Dannis
AU  - Wesseling, Pieter
AU  - La Madrid, Andrés Morales
AU  - Garrè, Maria Luisa
AU  - Antonelli, Manila
AU  - Giangaspero, Felice
AU  - Pietsch, Torsten
AU  - Sturm, Dominik
AU  - Jones, David T W
AU  - Pfister, Stefan M
AU  - Grabovska, Yura
AU  - Mackay, Alan
AU  - Jones, Chris
AU  - Grill, Jacques
AU  - Ajlil, Yassine
AU  - von Bueren, André O
AU  - Karremann, Michael
AU  - Hoffmann, Marion
AU  - Kramm, Christof M
AU  - Kwiecien, Robert
AU  - Castel, David
AU  - Gielen, Gerrit H
AU  - Varlet, Pascale
TI  - Diffuse pediatric high-grade glioma of methylation-based RTK2A and RTK2B subclasses present distinct radiological and histomolecular features including Gliomatosis cerebri phenotype.
JO  - Acta Neuropathologica Communications
VL  - 12
IS  - 1
SN  - 2051-5960
CY  - London
PB  - Biomed Central
M1  - DKFZ-2024-02358
SP  - 176
PY  - 2024
AB  - Diffuse pediatric-type high-grade gliomas (pedHGG), H3- and IDH-wildtype, encompass three main DNA-methylation-based subtypes: pedHGG-MYCN, pedHGG-RTK1A/B/C, and pedHGG-RTK2A/B. Since their first description in 2017 tumors of pedHGG-RTK2A/B have not been comprehensively characterized and clinical correlates remain elusive. In a recent series of pedHGG with a Gliomatosis cerebri (GC) growth pattern, an increased incidence of pedHGG-RTK2A/B (n = 18) was observed. We added 14 epigenetically defined pedHGG-RTK2A/B tumors to this GC series and provided centrally reviewed radiological, histological, and molecular characterization. The final cohort of 32 pedHGG-RTK2A/B tumors consisted of 25 pedHGG-RTK2A (78
KW  - Humans
KW  - Child
KW  - Male
KW  - Female
KW  - Brain Neoplasms: genetics
KW  - Brain Neoplasms: pathology
KW  - Brain Neoplasms: diagnostic imaging
KW  - Adolescent
KW  - Child, Preschool
KW  - Neoplasms, Neuroepithelial: genetics
KW  - Neoplasms, Neuroepithelial: pathology
KW  - Neoplasms, Neuroepithelial: diagnostic imaging
KW  - DNA Methylation
KW  - Glioma: genetics
KW  - Glioma: pathology
KW  - Glioma: diagnostic imaging
KW  - Phenotype
KW  - Gliomatosis cerebri (Other)
KW  - Methylation (Other)
KW  - Pediatric high-grade glioma (Other)
KW  - RTK2A (Other)
KW  - RTK2B (Other)
KW  - Receptor tyrosine kinase (Other)
KW  - pedHGG (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:39558399
C2  - pmc:PMC11575044
DO  - DOI:10.1186/s40478-024-01881-1
UR  - https://inrepo02.dkfz.de/record/294583
ER  -