000294668 001__ 294668
000294668 005__ 20250113113006.0
000294668 0247_ $$2doi$$a10.1038/s41416-024-02900-7
000294668 0247_ $$2pmid$$apmid:39580580
000294668 0247_ $$2ISSN$$a0007-0920
000294668 0247_ $$2ISSN$$a1532-1827
000294668 037__ $$aDKFZ-2024-02403
000294668 041__ $$aEnglish
000294668 082__ $$a610
000294668 1001_ $$00000-0001-7090-6551$$aChan, Wing Ching$$b0
000294668 245__ $$aAssociations of blood lipids and LDL cholesterol lowering drug-targets with colorectal cancer risk: a Mendelian randomisation study.
000294668 260__ $$aEdinburgh$$bNature Publ. Group$$c2025
000294668 3367_ $$2DRIVER$$aarticle
000294668 3367_ $$2DataCite$$aOutput Types/Journal article
000294668 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1736764160_11874
000294668 3367_ $$2BibTeX$$aARTICLE
000294668 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000294668 3367_ $$00$$2EndNote$$aJournal Article
000294668 500__ $$a2025 Jan;132(1):103-110
000294668 520__ $$aWhether blood lipids are causally associated with colorectal cancer (CRC) risk remains unclear.Using two-sample Mendelian randomisation (MR), our study examined the associations of genetically-predicted blood concentrations of lipids and lipoproteins (primary: LDL-C, HDL-C, triglycerides, and total cholesterol), and genetically-proxied inhibition of HMGCR, NPC1L1, and PCSK9 (which mimic therapeutic effects of LDL-lowering drugs), with risks of CRC and its subsites. Genetic associations with lipids were obtained from the Global Lipids Genetics Consortium (n = 1,320,016), while genetic associations with CRC were obtained from the largest existing CRC consortium (n = 58,221 cases and 67,694 controls). Our main analysis was a multivariable MR (MVMR) with mutual adjustments for LDL-C, HDL-C, and triglycerides. Secondary analyses, including MVMR additionally-adjusting for BMI or diabetes, were also performed.Genetically-predicted LDL-C was positively associated with CRC risk in the MVMR adjusted for HDL-C and triglycerides (OR = 1.09; 95%CI 1.02-1.16 per SD increase) and additionally-adjusted for BMI (OR = 1.12; 95%CI 1.05-1.21) or diabetes (OR = 1.09; 95%CI 1.02-1.17). Associations were generally consistent across anatomical subsites. No clear evidence of association was found for other lipids, lipoproteins, or LDL-lowering drug-targets.We found evidence of a weak positive association between LDL-C and CRC that did not appear to be explained by potential pleiotropic pathways such as via HDL-C, triglycerides, BMI, or diabetes.
000294668 536__ $$0G:(DE-HGF)POF4-313$$a313 - Krebsrisikofaktoren und Prävention (POF4-313)$$cPOF4-313$$fPOF IV$$x0
000294668 588__ $$aDataset connected to CrossRef, PubMed, , Journals: inrepo02.dkfz.de
000294668 7001_ $$aLiu, Lili$$b1
000294668 7001_ $$00000-0003-1489-5506$$aBouras, Emmanouil$$b2
000294668 7001_ $$aZuber, Verena$$b3
000294668 7001_ $$aWen, Wanqing$$b4
000294668 7001_ $$aLong, Jirong$$b5
000294668 7001_ $$00000-0001-7312-7078$$aGill, Dipender$$b6
000294668 7001_ $$00000-0003-3347-8249$$aMurphy, Neil$$b7
000294668 7001_ $$aGunter, Marc J$$b8
000294668 7001_ $$00000-0003-2349-0009$$aAssimes, Themistocles L$$b9
000294668 7001_ $$aBujanda, Luis$$b10
000294668 7001_ $$00000-0001-8656-7822$$aGruber, Stephen B$$b11
000294668 7001_ $$00000-0001-5497-0465$$aKüry, Sébastien$$b12
000294668 7001_ $$00000-0001-8060-547X$$aLynch, Brigid M$$b13
000294668 7001_ $$aQu, Conghui$$b14
000294668 7001_ $$00000-0001-9337-7015$$aThomas, Minta$$b15
000294668 7001_ $$aWhite, Emily$$b16
000294668 7001_ $$aWoods, Michael O$$b17
000294668 7001_ $$00000-0001-5666-9318$$aPeters, Ulrike$$b18
000294668 7001_ $$aLi, Christopher I$$b19
000294668 7001_ $$00000-0001-7284-6767$$aChan, Andrew T$$b20
000294668 7001_ $$0P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aBrenner, Hermann$$b21$$udkfz
000294668 7001_ $$00000-0002-8452-8472$$aTsilidis, Konstantinos K$$b22
000294668 7001_ $$aZheng, Wei$$b23
000294668 773__ $$0PERI:(DE-600)2002452-6$$a10.1038/s41416-024-02900-7$$n1$$p103-110$$tBritish journal of cancer$$v132$$x0007-0920$$y2025
000294668 909CO $$ooai:inrepo02.dkfz.de:294668$$pVDB
000294668 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aDeutsches Krebsforschungszentrum$$b21$$kDKFZ
000294668 9131_ $$0G:(DE-HGF)POF4-313$$1G:(DE-HGF)POF4-310$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vKrebsrisikofaktoren und Prävention$$x0
000294668 9141_ $$y2024
000294668 915__ $$0StatID:(DE-HGF)3002$$2StatID$$aDEAL Springer$$d2023-10-22$$wger
000294668 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2023-10-22
000294668 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2023-10-22
000294668 915__ $$0StatID:(DE-HGF)0320$$2StatID$$aDBCoverage$$bPubMed Central$$d2023-10-22
000294668 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2023-10-22
000294668 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2023-10-22
000294668 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2023-10-22
000294668 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2023-10-22
000294668 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences$$d2023-10-22
000294668 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2023-10-22
000294668 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2023-10-22
000294668 915__ $$0StatID:(DE-HGF)1110$$2StatID$$aDBCoverage$$bCurrent Contents - Clinical Medicine$$d2023-10-22
000294668 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bBRIT J CANCER : 2022$$d2023-10-22
000294668 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search$$d2023-10-22
000294668 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC$$d2023-10-22
000294668 915__ $$0StatID:(DE-HGF)9905$$2StatID$$aIF >= 5$$bBRIT J CANCER : 2022$$d2023-10-22
000294668 9201_ $$0I:(DE-He78)C070-20160331$$kC070$$lC070 Klinische Epidemiologie und Alternf.$$x0
000294668 9201_ $$0I:(DE-He78)C120-20160331$$kC120$$lPräventive Onkologie$$x1
000294668 9201_ $$0I:(DE-He78)HD01-20160331$$kHD01$$lDKTK HD zentral$$x2
000294668 980__ $$ajournal
000294668 980__ $$aVDB
000294668 980__ $$aI:(DE-He78)C070-20160331
000294668 980__ $$aI:(DE-He78)C120-20160331
000294668 980__ $$aI:(DE-He78)HD01-20160331
000294668 980__ $$aUNRESTRICTED