TY  - JOUR
AU  - Tan, Josephine L
AU  - Kalia, Vibhuti
AU  - Pautler, Stephen E
AU  - Bauman, Glenn
AU  - Gast, Lena V
AU  - Müller, Max
AU  - Nagel, Armin
AU  - Thiessen, Jonathan D
AU  - Scholl, Timothy J
AU  - Akbari, Alireza
TI  - Different sodium concentrations of noncancerous and cancerous prostate tissue seen on MRI using an external coil.
JO  - Radiology advances
VL  - 1
IS  - 3
SN  - 2976-9337
CY  - Oak Brook, Ill.
PB  - Radiological Society of North America (RSNA)
M1  - DKFZ-2024-02409
SP  - umae023
PY  - 2024
N1  - Radiology Advances () = 2976-9337 (import from CrossRef, PubMed, , Journals: inrepo02.dkfz.de)
AB  - Sodium (23Na) MRI of prostate cancer (PCa) is a novel but underdocumented technique conventionally acquired using an endorectal coil. These endorectal coils are associated with challenges (e.g., a nonuniform sensitivity profile, limited prostate coverage, patient discomfort) that could be mitigated with an external 23Na MRI coil.To quantify tissue sodium concentration (TSC) differences within the prostate of participants with PCa and healthy volunteers using an external 23Na MRI radiofrequency coil at 3 T.A prospective study was conducted from January 2022 to June 2024 in healthy volunteers and participants with biopsy-proven PCa. Prostate 23Na MRI was acquired on a 3-T PET/MRI scanner using a custom-built 2-loop (diameter, 18 cm) butterfly surface coil tuned for the 23Na frequency (32.6 MHz). The percent difference in TSC (ΔTSC) between prostate cancer lesions and surrounding noncancerous prostate tissue of the peripheral zone (PZ) and transition zone (TZ) was evaluated using a 1-sample t-test. TSC was compared to apparent diffusion coefficient (ADC) measurements as a clinical reference.Six healthy volunteers (mean age, 54.5 years ± 12.7) and 20 participants with PCa (mean age, 70.7 years ± 8.3) were evaluated. A total of 31 lesions were detected (21 PZ, 10 TZ) across PCa participants. Compared to noncancerous prostate tissue, prostate cancer lesions had significantly lower TSC (ΔTSC, -14.1
KW  - 3 Tesla (Other)
KW  - apparent diffusion coefficient (Other)
KW  - human prostate cancer (Other)
KW  - sodium (23Na) MRI (Other)
KW  - tissue sodium concentration (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:39574514
C2  - pmc:PMC11578593
DO  - DOI:10.1093/radadv/umae023
UR  - https://inrepo02.dkfz.de/record/294674
ER  -