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@ARTICLE{Tan:294674,
      author       = {J. L. Tan and V. Kalia and S. E. Pautler and G. Bauman and
                      L. V. Gast and M. Müller and A. Nagel$^*$ and J. D.
                      Thiessen and T. J. Scholl and A. Akbari},
      title        = {{D}ifferent sodium concentrations of noncancerous and
                      cancerous prostate tissue seen on {MRI} using an external
                      coil.},
      journal      = {Radiology advances},
      volume       = {1},
      number       = {3},
      issn         = {2976-9337},
      address      = {Oak Brook, Ill.},
      publisher    = {Radiological Society of North America (RSNA)},
      reportid     = {DKFZ-2024-02409},
      pages        = {umae023},
      year         = {2024},
      note         = {Radiology Advances () = 2976-9337 (import from CrossRef,
                      PubMed, , Journals: inrepo02.dkfz.de)},
      abstract     = {Sodium (23Na) MRI of prostate cancer (PCa) is a novel but
                      underdocumented technique conventionally acquired using an
                      endorectal coil. These endorectal coils are associated with
                      challenges (e.g., a nonuniform sensitivity profile, limited
                      prostate coverage, patient discomfort) that could be
                      mitigated with an external 23Na MRI coil.To quantify tissue
                      sodium concentration (TSC) differences within the prostate
                      of participants with PCa and healthy volunteers using an
                      external 23Na MRI radiofrequency coil at 3 T.A prospective
                      study was conducted from January 2022 to June 2024 in
                      healthy volunteers and participants with biopsy-proven PCa.
                      Prostate 23Na MRI was acquired on a 3-T PET/MRI scanner
                      using a custom-built 2-loop (diameter, 18 cm) butterfly
                      surface coil tuned for the 23Na frequency (32.6 MHz). The
                      percent difference in TSC (ΔTSC) between prostate cancer
                      lesions and surrounding noncancerous prostate tissue of the
                      peripheral zone (PZ) and transition zone (TZ) was evaluated
                      using a 1-sample t-test. TSC was compared to apparent
                      diffusion coefficient (ADC) measurements as a clinical
                      reference.Six healthy volunteers (mean age, 54.5 years ±
                      12.7) and 20 participants with PCa (mean age, 70.7 years ±
                      8.3) were evaluated. A total of 31 lesions were detected (21
                      PZ, 10 TZ) across PCa participants. Compared to noncancerous
                      prostate tissue, prostate cancer lesions had significantly
                      lower TSC (ΔTSC, $-14.1\%$ ± 18.2, P = .0002) and ADC
                      (ΔADC, $-26.6\%$ ± 18.7, P < .0001).We used an external
                      23Na MRI coil for whole-gland comparison of TSC in PCa and
                      noncancerous prostate tissue at 3 T. PCa lesions presented
                      with lower TSC compared to surrounding noncancerous PZ and
                      TZ tissue. These findings demonstrate the feasibility of an
                      external 23Na MRI coil to quantify TSC in the prostate and
                      offer a promising, noninvasive approach to PCa diagnosis and
                      management.},
      keywords     = {3 Tesla (Other) / apparent diffusion coefficient (Other) /
                      human prostate cancer (Other) / sodium (23Na) MRI (Other) /
                      tissue sodium concentration (Other)},
      cin          = {E020},
      ddc          = {610},
      cid          = {I:(DE-He78)E020-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39574514},
      pmc          = {pmc:PMC11578593},
      doi          = {10.1093/radadv/umae023},
      url          = {https://inrepo02.dkfz.de/record/294674},
}