%0 Journal Article
%A Leppä, Aino-Maija
%A Grimes, Karen
%A Jeong, Hyobin
%A Huang, Frank Yi-Tao
%A Andrades, Alvaro
%A Waclawiczek, Alexander
%A Boch, Tobias
%A Jauch, Anna
%A Renders, Simon
%A Stelmach, Patrick
%A Müller-Tidow, Carsten
%A Karpova, Darja
%A Sohn, Markus
%A Grünschläger, Florian
%A Hasenfeld, Patrick
%A Benito Garagorri, Eva
%A Thiel, Vera
%A Dolnik, Anna
%A Rodriguez-Martin, Bernardo
%A Bullinger, Lars
%A Mrózek, Krzysztof
%A Eisfeld, Ann-Kathrin
%A Krämer, Alwin
%A Sanders, Ashley D
%A Korbel, Jan
%A Trumpp, Andreas
%T Single-cell multiomics analysis reveals dynamic clonal evolution and targetable phenotypes in acute myeloid leukemia with complex karyotype.
%J Nature genetics
%V 56
%N 12
%@ 1061-4036
%C London
%I Macmillan Publishers Limited, part of Springer Nature
%M DKFZ-2024-02422
%P 2790-2803
%D 2024
%Z DKFZ-ZMBH Alliance / #EA:A010#LA:A010#LA:B480# / 2024 Dec;56(12):2790-2803
%X Chromosomal instability is a major driver of intratumoral heterogeneity (ITH), promoting tumor progression. In the present study, we combined structural variant discovery and nucleosome occupancy profiling with transcriptomic and immunophenotypic changes in single cells to study ITH in complex karyotype acute myeloid leukemia (CK-AML). We observed complex structural variant landscapes within individual cells of patients with CK-AML characterized by linear and circular breakage-fusion-bridge cycles and chromothripsis. We identified three clonal evolution patterns in diagnosis or salvage CK-AML (monoclonal, linear and branched polyclonal), with 75
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:39587361
%R 10.1038/s41588-024-01999-x
%U https://inrepo02.dkfz.de/record/294687