TY  - JOUR
AU  - Leppä, Aino-Maija
AU  - Grimes, Karen
AU  - Jeong, Hyobin
AU  - Huang, Frank Yi-Tao
AU  - Andrades, Alvaro
AU  - Waclawiczek, Alexander
AU  - Boch, Tobias
AU  - Jauch, Anna
AU  - Renders, Simon
AU  - Stelmach, Patrick
AU  - Müller-Tidow, Carsten
AU  - Karpova, Darja
AU  - Sohn, Markus
AU  - Grünschläger, Florian
AU  - Hasenfeld, Patrick
AU  - Benito Garagorri, Eva
AU  - Thiel, Vera
AU  - Dolnik, Anna
AU  - Rodriguez-Martin, Bernardo
AU  - Bullinger, Lars
AU  - Mrózek, Krzysztof
AU  - Eisfeld, Ann-Kathrin
AU  - Krämer, Alwin
AU  - Sanders, Ashley D
AU  - Korbel, Jan
AU  - Trumpp, Andreas
TI  - Single-cell multiomics analysis reveals dynamic clonal evolution and targetable phenotypes in acute myeloid leukemia with complex karyotype.
JO  - Nature genetics
VL  - 56
IS  - 12
SN  - 1061-4036
CY  - London
PB  - Macmillan Publishers Limited, part of Springer Nature
M1  - DKFZ-2024-02422
SP  - 2790-2803
PY  - 2024
N1  - DKFZ-ZMBH Alliance / #EA:A010#LA:A010#LA:B480# / 2024 Dec;56(12):2790-2803
AB  - Chromosomal instability is a major driver of intratumoral heterogeneity (ITH), promoting tumor progression. In the present study, we combined structural variant discovery and nucleosome occupancy profiling with transcriptomic and immunophenotypic changes in single cells to study ITH in complex karyotype acute myeloid leukemia (CK-AML). We observed complex structural variant landscapes within individual cells of patients with CK-AML characterized by linear and circular breakage-fusion-bridge cycles and chromothripsis. We identified three clonal evolution patterns in diagnosis or salvage CK-AML (monoclonal, linear and branched polyclonal), with 75
LB  - PUB:(DE-HGF)16
C6  - pmid:39587361
DO  - DOI:10.1038/s41588-024-01999-x
UR  - https://inrepo02.dkfz.de/record/294687
ER  -