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000294688 1001_ $$aPapadimitriou, Nikos$$b0
000294688 245__ $$aBody mass index at birth and early life and colorectal cancer: A two-sample Mendelian randomization analysis in European and East Asian genetic similarity populations.
000294688 260__ $$aMalden, Mass.$$bWiley$$c2025
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000294688 520__ $$aVarying obesogenic inherited predisposition in early to later life may differentially impact colorectal cancer (CRC) development. Previous Mendelian randomization (MR) studies, conducted in populations of European genetic similarity, have not observed any significant associations between early life body weight with CRC risk. However, it remains unclear whether body mass index (BMI) at different early lifetime points is causally related with CRC risk in both Europeans and East Asian populations.We conducted a two-sample MR study to investigate potential causal relationships between genetically predicted BMI during early life (birth to 8 years old) and at specific periods (birth, transient, early rise and late rise) and CRC risk.Summary data were obtained from genome-wide association study (GWAS) of BMI in 28 681 children from the Norwegian Mother, Father and Child Cohort Study (MoBa) study and applied to CRC GWAS data from European and East Asian descent populations (102 893 cases and 485 083 non-cases).There were no significant associations observed between early life BMI and CRC risk in European or East Asian populations. The effect estimates were similar in European studies (odds ratio [OR] per a 1-standard deviation [SD] increase: 1.01, 95% confidence interval [CI]: 0.95, 1.07) and in East Asians (OR per a 1-SD increase: 1.02, 95% CI: 0.91, 1.14). Similar nonsignificant associations were found between time of BMI measurement during childhood and cancer-site-specific analyses.We found little evidence of any associations between early life adiposity on later life CRC risk.
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000294688 650_7 $$2Other$$acolorectal cancer
000294688 650_7 $$2Other$$aearly life
000294688 650_7 $$2Other$$amendelian randomization
000294688 650_7 $$2Other$$aobesity
000294688 7001_ $$aMurphy, Neil$$b1
000294688 7001_ $$aJenab, Mazda$$b2
000294688 7001_ $$aChen, Zhishan$$b3
000294688 7001_ $$0P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aBrenner, Hermann$$b4$$udkfz
000294688 7001_ $$aKweon, Sun-Seog$$b5
000294688 7001_ $$aLe Marchand, Loic$$b6
000294688 7001_ $$aMoreno, Victor$$b7
000294688 7001_ $$aPlatz, Elizabeth A$$b8
000294688 7001_ $$avan Duijnhoven, Fränzel J B$$b9
000294688 7001_ $$aCheng, Iona$$b10
000294688 7001_ $$aPai, Rish K$$b11
000294688 7001_ $$aPhipps, Amanda I$$b12
000294688 7001_ $$aPeters, Ulrike$$b13
000294688 7001_ $$aZheng, Wei$$b14
000294688 7001_ $$00000-0003-1668-8770$$aHughes, David J$$b15
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