TY  - JOUR
AU  - Papadimitriou, Nikos
AU  - Murphy, Neil
AU  - Jenab, Mazda
AU  - Chen, Zhishan
AU  - Brenner, Hermann
AU  - Kweon, Sun-Seog
AU  - Le Marchand, Loic
AU  - Moreno, Victor
AU  - Platz, Elizabeth A
AU  - van Duijnhoven, Fränzel J B
AU  - Cheng, Iona
AU  - Pai, Rish K
AU  - Phipps, Amanda I
AU  - Peters, Ulrike
AU  - Zheng, Wei
AU  - Hughes, David J
TI  - Body mass index at birth and early life and colorectal cancer: A two-sample Mendelian randomization analysis in European and East Asian genetic similarity populations.
JO  - Pediatric obesity
VL  - 20
IS  - 1
SN  - 2047-6302
CY  - Malden, Mass.
PB  - Wiley
M1  - DKFZ-2024-02423
SP  - e13186
PY  - 2025
N1  - 2025 Jan;20(1):e13186
AB  - Varying obesogenic inherited predisposition in early to later life may differentially impact colorectal cancer (CRC) development. Previous Mendelian randomization (MR) studies, conducted in populations of European genetic similarity, have not observed any significant associations between early life body weight with CRC risk. However, it remains unclear whether body mass index (BMI) at different early lifetime points is causally related with CRC risk in both Europeans and East Asian populations.We conducted a two-sample MR study to investigate potential causal relationships between genetically predicted BMI during early life (birth to 8 years old) and at specific periods (birth, transient, early rise and late rise) and CRC risk.Summary data were obtained from genome-wide association study (GWAS) of BMI in 28 681 children from the Norwegian Mother, Father and Child Cohort Study (MoBa) study and applied to CRC GWAS data from European and East Asian descent populations (102 893 cases and 485 083 non-cases).There were no significant associations observed between early life BMI and CRC risk in European or East Asian populations. The effect estimates were similar in European studies (odds ratio [OR] per a 1-standard deviation [SD] increase: 1.01, 95
KW  - colorectal cancer (Other)
KW  - early life (Other)
KW  - mendelian randomization (Other)
KW  - obesity (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:39587448
DO  - DOI:10.1111/ijpo.13186
UR  - https://inrepo02.dkfz.de/record/294688
ER  -