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@ARTICLE{Papadimitriou:294688,
      author       = {N. Papadimitriou and N. Murphy and M. Jenab and Z. Chen and
                      H. Brenner$^*$ and S.-S. Kweon and L. Le Marchand and V.
                      Moreno and E. A. Platz and F. J. B. van Duijnhoven and I.
                      Cheng and R. K. Pai and A. I. Phipps and U. Peters and W.
                      Zheng and D. J. Hughes},
      title        = {{B}ody mass index at birth and early life and colorectal
                      cancer: {A} two-sample {M}endelian randomization analysis in
                      {E}uropean and {E}ast {A}sian genetic similarity
                      populations.},
      journal      = {Pediatric obesity},
      volume       = {20},
      number       = {1},
      issn         = {2047-6302},
      address      = {Malden, Mass.},
      publisher    = {Wiley},
      reportid     = {DKFZ-2024-02423},
      pages        = {e13186},
      year         = {2025},
      note         = {2025 Jan;20(1):e13186},
      abstract     = {Varying obesogenic inherited predisposition in early to
                      later life may differentially impact colorectal cancer (CRC)
                      development. Previous Mendelian randomization (MR) studies,
                      conducted in populations of European genetic similarity,
                      have not observed any significant associations between early
                      life body weight with CRC risk. However, it remains unclear
                      whether body mass index (BMI) at different early lifetime
                      points is causally related with CRC risk in both Europeans
                      and East Asian populations.We conducted a two-sample MR
                      study to investigate potential causal relationships between
                      genetically predicted BMI during early life (birth to 8
                      years old) and at specific periods (birth, transient, early
                      rise and late rise) and CRC risk.Summary data were obtained
                      from genome-wide association study (GWAS) of BMI in 28 681
                      children from the Norwegian Mother, Father and Child Cohort
                      Study (MoBa) study and applied to CRC GWAS data from
                      European and East Asian descent populations (102 893 cases
                      and 485 083 non-cases).There were no significant
                      associations observed between early life BMI and CRC risk in
                      European or East Asian populations. The effect estimates
                      were similar in European studies (odds ratio [OR] per a
                      1-standard deviation [SD] increase: 1.01, $95\%$ confidence
                      interval [CI]: 0.95, 1.07) and in East Asians (OR per a 1-SD
                      increase: 1.02, $95\%$ CI: 0.91, 1.14). Similar
                      nonsignificant associations were found between time of BMI
                      measurement during childhood and cancer-site-specific
                      analyses.We found little evidence of any associations
                      between early life adiposity on later life CRC risk.},
      keywords     = {colorectal cancer (Other) / early life (Other) / mendelian
                      randomization (Other) / obesity (Other)},
      cin          = {C070 / HD01 / C120},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)HD01-20160331 /
                      I:(DE-He78)C120-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39587448},
      doi          = {10.1111/ijpo.13186},
      url          = {https://inrepo02.dkfz.de/record/294688},
}