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000294723 1001_ $$00000-0003-4192-6523$$aJessa, Selin$$b0
000294723 245__ $$aFOXR2 targets LHX6+/DLX+ neural lineages to drive CNS neuroblastoma.
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000294723 500__ $$a2025 Jan 15;85(2):231-250
000294723 520__ $$aCentral nervous system neuroblastoma with FOXR2 activation (NB-FOXR2) is a high-grade tumor of the brain hemispheres and a newly identified molecular entity. Tumors express dual neuronal and glial markers, leading to frequent misdiagnoses, and limited information exists on the role of FOXR2 in their genesis. To identify their cellular origins, we profiled the transcriptomes of NB-FOXR2 tumors at the bulk and single-cell levels and integrated these profiles with large single-cell references of the normal brain. NB-FOXR2 tumors mapped to LHX6+/DLX+ lineages derived from the medial ganglionic eminence, a progenitor domain in the ventral telencephalon. In vivo prenatal Foxr2 targeting to the ganglionic eminences in mice induced postnatal cortical tumors recapitulating human NB-FOXR2 specific molecular signatures. Profiling of FOXR2 binding on chromatin in murine models revealed an association with ETS transcriptional networks, as well as direct binding of FOXR2 at key transcription factors that coordinate initiation of gliogenesis. These data indicate that NB-FOXR2 originate from LHX6+/DLX+ interneuron lineages, a lineage-of-origin distinct from that of other FOXR2-driven brain tumors, highlight the susceptibility of ventral telencephalon-derived interneurons to FOXR2-driven oncogenesis, and suggest that FOXR2-induced activation of glial programs may explain the mixed neuronal and oligodendroglial features in these tumors. More broadly, this work underscores systematic profiling of brain development as an efficient approach to orient oncogenic targeting for in vivo modeling, critical for the study of rare tumors and development of therapeutics.
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000294723 7001_ $$00000-0002-3202-5339$$aDe Cola, Antonella$$b1
000294723 7001_ $$00009-0002-7972-2892$$aChandarana, Bhavyaa$$b2
000294723 7001_ $$00000-0002-6920-9924$$aMcNicholas, Michael$$b3
000294723 7001_ $$00000-0001-6267-8595$$aHébert, Steven$$b4
000294723 7001_ $$00009-0000-5020-1722$$aPtack, Adam$$b5
000294723 7001_ $$00000-0003-1584-599X$$aFaury, Damien$$b6
000294723 7001_ $$00000-0003-0540-4330$$aTsai, Jessica W$$b7
000294723 7001_ $$0P:(DE-He78)8d9c904a6cea14d4c99c78ba46e41f93$$aKorshunov, Andrey$$b8$$udkfz
000294723 7001_ $$00000-0003-4771-4003$$aPhoenix, Timothy N$$b9
000294723 7001_ $$00000-0002-8716-7924$$aEllezam, Benjamin$$b10
000294723 7001_ $$0P:(DE-He78)551bb92841f634070997aa168d818492$$aJones, David$$b11$$udkfz
000294723 7001_ $$00000-0001-7009-3466$$aTaylor, Michael D$$b12
000294723 7001_ $$00000-0002-4175-4760$$aBandopadhayay, Pratiti$$b13
000294723 7001_ $$00000-0001-5635-5028$$aPathania, Manav$$b14
000294723 7001_ $$00000-0003-2485-3692$$aJabado, Nada$$b15
000294723 7001_ $$00000-0002-5158-7126$$aKleinman, Claudia L$$b16
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