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@ARTICLE{Jessa:294723,
      author       = {S. Jessa and A. De Cola and B. Chandarana and M. McNicholas
                      and S. Hébert and A. Ptack and D. Faury and J. W. Tsai and
                      A. Korshunov$^*$ and T. N. Phoenix and B. Ellezam and D.
                      Jones$^*$ and M. D. Taylor and P. Bandopadhayay and M.
                      Pathania and N. Jabado and C. L. Kleinman},
      title        = {{FOXR}2 targets {LHX}6+/{DLX}+ neural lineages to drive
                      {CNS} neuroblastoma.},
      journal      = {Cancer research},
      volume       = {85},
      number       = {2},
      issn         = {0099-7013},
      address      = {Philadelphia, Pa.},
      publisher    = {AACR},
      reportid     = {DKFZ-2024-02456},
      pages        = {231-250},
      year         = {2025},
      note         = {2025 Jan 15;85(2):231-250},
      abstract     = {Central nervous system neuroblastoma with FOXR2 activation
                      (NB-FOXR2) is a high-grade tumor of the brain hemispheres
                      and a newly identified molecular entity. Tumors express dual
                      neuronal and glial markers, leading to frequent
                      misdiagnoses, and limited information exists on the role of
                      FOXR2 in their genesis. To identify their cellular origins,
                      we profiled the transcriptomes of NB-FOXR2 tumors at the
                      bulk and single-cell levels and integrated these profiles
                      with large single-cell references of the normal brain.
                      NB-FOXR2 tumors mapped to LHX6+/DLX+ lineages derived from
                      the medial ganglionic eminence, a progenitor domain in the
                      ventral telencephalon. In vivo prenatal Foxr2 targeting to
                      the ganglionic eminences in mice induced postnatal cortical
                      tumors recapitulating human NB-FOXR2 specific molecular
                      signatures. Profiling of FOXR2 binding on chromatin in
                      murine models revealed an association with ETS
                      transcriptional networks, as well as direct binding of FOXR2
                      at key transcription factors that coordinate initiation of
                      gliogenesis. These data indicate that NB-FOXR2 originate
                      from LHX6+/DLX+ interneuron lineages, a lineage-of-origin
                      distinct from that of other FOXR2-driven brain tumors,
                      highlight the susceptibility of ventral
                      telencephalon-derived interneurons to FOXR2-driven
                      oncogenesis, and suggest that FOXR2-induced activation of
                      glial programs may explain the mixed neuronal and
                      oligodendroglial features in these tumors. More broadly,
                      this work underscores systematic profiling of brain
                      development as an efficient approach to orient oncogenic
                      targeting for in vivo modeling, critical for the study of
                      rare tumors and development of therapeutics.},
      cin          = {B300 / HD01 / B360},
      ddc          = {610},
      cid          = {I:(DE-He78)B300-20160331 / I:(DE-He78)HD01-20160331 /
                      I:(DE-He78)B360-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39495206},
      doi          = {10.1158/0008-5472.CAN-24-2248},
      url          = {https://inrepo02.dkfz.de/record/294723},
}