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@ARTICLE{Neelsen:294751,
      author       = {C. J. O. Neelsen$^*$ and C. Sachpekidis$^*$ and L. John and
                      P. Neher$^*$ and E. Mai and M. Grözinger$^*$ and D.
                      Paech$^*$ and A. Dimitrakopoulou-Strauss$^*$ and F. T.
                      Kurz$^*$ and S. Sauer and M. S. Raab and H.-P. Schlemmer$^*$
                      and M. Wennmann$^*$ and N. Weinhold},
      title        = {{S}plenic {T}2 signal intensity loss on {MRI} is associated
                      with disease burden in multiple myeloma.},
      journal      = {European radiology},
      volume       = {35},
      number       = {6},
      issn         = {0938-7994},
      address      = {Heidelberg},
      publisher    = {Springer},
      reportid     = {DKFZ-2024-02466},
      pages        = {3576-3586},
      year         = {2025},
      note         = {#EA:E010# / 2025 Jun;35(6):3576-3586},
      abstract     = {This study aims to evaluate correlations between spleen
                      signal changes in different MRI sequences and bone marrow
                      plasma cell infiltration as potential indicator of disease
                      burden in multiple myeloma (MM) patients.We retrospectively
                      analyzed 45 patients with newly diagnosed MM that underwent
                      whole-body MRI with axial DWI at b-values 50 (b50) and 800
                      (b800), and coronal T1 and T2 fast spin-echo (T2-TSE)
                      imaging. A subcohort of 39 patients had concomitant [18F]FDG
                      PET/CT. The spleen was segmented in all MRI sequences and
                      signal intensities were normalized. MR signal intensities
                      and ADC values were correlated with bone marrow plasma cell
                      infiltration from biopsy, laboratory markers (Beta
                      2-microglobulin, M-Protein, Red blood count (RBC),
                      Hemoglobin, Hematocrit, Total protein, Creatinine), clinical
                      data (ISS stages, high-risk chromosomal aberrations), and
                      standardized uptake value (SUV) in the spleen as well as
                      spleen-to-liver and spleen-to-blood pool SUV ratios on
                      [18F]FDG PET-CT.Bone marrow plasma cell infiltration was
                      negatively correlated with (normalized) mean splenic signal
                      intensity on DWI-b50, DWI-b800, and T2-TSE images (r =
                      -0.64, p < 0.001, r = -0.58, p < 0.001, and r = -0.66, p <
                      0.001, respectively) while there was no correlation with the
                      apparent diffusion coefficient or spleen size (p = 0.52). In
                      the subgroup analysis of 39 patients with concomitant
                      [18F]FDG PET-CT, there was no correlation of normalized
                      splenic [18F]FDG uptake either with MR spleen signal (for T2
                      p = 0.64) or with bone marrow plasma cell infiltration (p =
                      0.37).Our findings reveal a significant association between
                      spleen signal intensity especially on normalized T2-weighted
                      images and tumor burden.Question What changes occur in
                      spleen signal on MRI as tumor load marker changes in
                      multiple myeloma (MM)? Findings Spleen signal intensity,
                      particularly on T2-weighted MRI, negatively correlates with
                      bone marrow plasma cell infiltration and laboratory markers
                      of tumor burden. Clinical relevance Standardized
                      quantification of splenic T2 signal is proposed as a new
                      marker for MM disease burden.},
      keywords     = {Multiparametric magnetic resonance imaging (Other) /
                      Multiple myeloma (Other) / Neoplasm staging (Other) /
                      Positron emission tomography computed tomography (Other) /
                      Spleen (Other)},
      cin          = {E010 / E060 / E230},
      ddc          = {610},
      cid          = {I:(DE-He78)E010-20160331 / I:(DE-He78)E060-20160331 /
                      I:(DE-He78)E230-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39604650},
      doi          = {10.1007/s00330-024-11191-8},
      url          = {https://inrepo02.dkfz.de/record/294751},
}