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000294804 1001_ $$0P:(DE-He78)368cffed46c9727340333e3279d0f2c5$$aGröninger, Mareike$$b0$$eFirst author$$udkfz
000294804 245__ $$aAssociations of milk, dairy products, calcium and vitamin D intake with risk of developing Parkinson´s disease within the EPIC4ND cohort.
000294804 260__ $$aDordrecht [u.a.]$$bSpringer Science + Business Media B.V.$$c2024
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000294804 500__ $$a#EA:C020#LA:C020# / 2024 Nov;39(11):1251-1265
000294804 520__ $$aLiterature indicates a potential association between dairy consumption and risk of Parkinson´s disease (PD), especially among men, yet the results remain inconclusive. We investigated this association in a large prospective European cohort. Dietary and non-dietary data was collected from 183,225 participants of the EPIC-for-Neurodegenerative-Diseases (EPIC4ND) cohort, a sub-cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Crude and multivariable-adjusted Cox proportional hazards models were employed to examine potential associations between baseline dietary intake of dairy, calcium and vitamin D with incident PD risk. No relationship was observed between dairy consumption (HR 1.07, 95% CI 0.82-1.39), individual dairy products (milk: HR 0.95, 95% CI 0.73-1.23; yogurt: HR 1.03, 95% CI 0.82-1.29; cheese: HR 1.13, 95% CI 0.85-1.51), or vitamin D (HR 1.08, 95% CI 0.80-1.45) with PD risk. However, we observed a risk-increasing association with higher calcium intakes (HR 1.33, 95% CI 1.00-1.78, p for trend = 0.031), which was more pronounced in men (HR 1.50, 95% CI 1.00-2.25, p for trend = 0.044) and in ever smokers (HR 1.64, 95% CI 1.06-2.53, p for trend = 0.014). No compelling evidence was found for an association between dairy products or vitamin D intake and PD risk indicating a potentially limited relevance of dairy intake in PD risk than previously described. Our observations of a positive association between dietary calcium intake and PD risk in men and in ever smokers require further validation.
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000294804 650_7 $$2Other$$aCalcium
000294804 650_7 $$2Other$$aDairy
000294804 650_7 $$2Other$$aEPIC
000294804 650_7 $$2Other$$aParkinson´s disease
000294804 650_7 $$2Other$$aVitamin D
000294804 7001_ $$0P:(DE-He78)18b6fde740d8238c47673a8a50a4d92b$$aSabin, Jara$$b1$$udkfz
000294804 7001_ $$0P:(DE-He78)4b2dc91c9d1ac33a1c0e0777d0c1697a$$aKaaks, Rudolf$$b2$$udkfz
000294804 7001_ $$00000-0003-3986-7026$$aAmiano, Pilar$$b3
000294804 7001_ $$00000-0002-4533-1722$$aAune, Dagfinn$$b4
000294804 7001_ $$aCastro, Natalia Cabrera$$b5
000294804 7001_ $$aGuevara, Marcela$$b6
000294804 7001_ $$00000-0002-9342-2725$$aHansen, Johnni$$b7
000294804 7001_ $$00000-0003-2791-7065$$aHomann, Jan$$b8
000294804 7001_ $$aMasala, Giovanna$$b9
000294804 7001_ $$00000-0001-7871-7149$$aNicolas, Geneviève$$b10
000294804 7001_ $$00000-0001-5662-1971$$aPeters, Susan$$b11
000294804 7001_ $$00000-0002-8008-5096$$aSacerdote, Carlotta$$b12
000294804 7001_ $$aSánchez, Maria-Jose$$b13
000294804 7001_ $$aDe Magistris, Maria Santucci$$b14
000294804 7001_ $$aSieri, Sabina$$b15
000294804 7001_ $$aVermeulen, Roel$$b16
000294804 7001_ $$00000-0002-5275-0036$$aZhao, Yujia$$b17
000294804 7001_ $$aLill, Christina M$$b18
000294804 7001_ $$0P:(DE-He78)fb68a9386399d72d84f7f34cfc6048b4$$aKatzke, Verena$$b19$$eLast author$$udkfz
000294804 773__ $$0PERI:(DE-600)2004992-4$$a10.1007/s10654-024-01183-9$$n11$$p1251-1265$$tEuropean journal of epidemiology$$v39$$x0393-2990$$y2024
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