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@ARTICLE{Grninger:294804,
      author       = {M. Gröninger$^*$ and J. Sabin$^*$ and R. Kaaks$^*$ and P.
                      Amiano and D. Aune and N. C. Castro and M. Guevara and J.
                      Hansen and J. Homann and G. Masala and G. Nicolas and S.
                      Peters and C. Sacerdote and M.-J. Sánchez and M. S. De
                      Magistris and S. Sieri and R. Vermeulen and Y. Zhao and C.
                      M. Lill and V. Katzke$^*$},
      title        = {{A}ssociations of milk, dairy products, calcium and vitamin
                      {D} intake with risk of developing {P}arkinson´s disease
                      within the {EPIC}4{ND} cohort.},
      journal      = {European journal of epidemiology},
      volume       = {39},
      number       = {11},
      issn         = {0393-2990},
      address      = {Dordrecht [u.a.]},
      publisher    = {Springer Science + Business Media B.V.},
      reportid     = {DKFZ-2024-02516},
      pages        = {1251-1265},
      year         = {2024},
      note         = {#EA:C020#LA:C020# / 2024 Nov;39(11):1251-1265},
      abstract     = {Literature indicates a potential association between dairy
                      consumption and risk of Parkinson´s disease (PD),
                      especially among men, yet the results remain inconclusive.
                      We investigated this association in a large prospective
                      European cohort. Dietary and non-dietary data was collected
                      from 183,225 participants of the
                      EPIC-for-Neurodegenerative-Diseases (EPIC4ND) cohort, a
                      sub-cohort of the European Prospective Investigation into
                      Cancer and Nutrition (EPIC) cohort. Crude and
                      multivariable-adjusted Cox proportional hazards models were
                      employed to examine potential associations between baseline
                      dietary intake of dairy, calcium and vitamin D with incident
                      PD risk. No relationship was observed between dairy
                      consumption (HR 1.07, $95\%$ CI 0.82-1.39), individual dairy
                      products (milk: HR 0.95, $95\%$ CI 0.73-1.23; yogurt: HR
                      1.03, $95\%$ CI 0.82-1.29; cheese: HR 1.13, $95\%$ CI
                      0.85-1.51), or vitamin D (HR 1.08, $95\%$ CI 0.80-1.45) with
                      PD risk. However, we observed a risk-increasing association
                      with higher calcium intakes (HR 1.33, $95\%$ CI 1.00-1.78, p
                      for trend = 0.031), which was more pronounced in men (HR
                      1.50, $95\%$ CI 1.00-2.25, p for trend = 0.044) and in ever
                      smokers (HR 1.64, $95\%$ CI 1.06-2.53, p for trend = 0.014).
                      No compelling evidence was found for an association between
                      dairy products or vitamin D intake and PD risk indicating a
                      potentially limited relevance of dairy intake in PD risk
                      than previously described. Our observations of a positive
                      association between dietary calcium intake and PD risk in
                      men and in ever smokers require further validation.},
      keywords     = {Calcium (Other) / Dairy (Other) / EPIC (Other) /
                      Parkinson´s disease (Other) / Vitamin D (Other)},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39625618},
      doi          = {10.1007/s10654-024-01183-9},
      url          = {https://inrepo02.dkfz.de/record/294804},
}