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@ARTICLE{Bavarsad:294825,
      author       = {S. B. Bavarsad and S. Shahryarhesami$^*$ and N. Karami and
                      N. Naseri and A. Tajbakhsh and S. M. Gheibihayat},
      title        = {{E}fferocytosis and infertility: {I}mplications for
                      diagnosis and therapy.},
      journal      = {Journal of reproductive immunology},
      volume       = {167},
      issn         = {0165-0378},
      address      = {Oxford},
      publisher    = {Oxford University Press},
      reportid     = {DKFZ-2024-02536},
      pages        = {104413},
      year         = {2025},
      abstract     = {Recent research has shed light on the intricate connection
                      between efferocytosis and infertility, revealing its
                      dysregulation as a contributing factor in various
                      reproductive diseases. Despite the multifaceted nature of
                      infertility etiology, the impact of insufficient clearance
                      of apoptotic cells on fertility has emerged as a focal
                      point. Notably, the removal of apoptotic cells through
                      phagocytosis in the female reproductive system has been a
                      subject of extensive investigation in the field of
                      infertility. Additionally, special functions performed by
                      immune system cell types, such as macrophages and Sertoli
                      cells, in the male reproductive system underscore their
                      significance in spermatogenesis and the efferocytosis of
                      apoptotic germ cells. Dysregulation of efferocytosis emerges
                      as a critical factor contributing to reproductive
                      challenges, such as low pregnancy rates, miscarriages, and
                      implantation failures. Moreover, defective efferocytosis can
                      lead to compromised implantation, recurrent miscarriages,
                      and unsuccessful assisted reproductive procedures. This
                      review article aims to provide a comprehensive overview of
                      efferocytosis in the context of infertility. Molecular
                      mechanisms underlying efferocytosis, its relevance in both
                      female and male infertility, and its implications in various
                      reproductive diseases are elucidated. The elucidation of the
                      intricate relationship between efferocytosis and infertility
                      not only facilitates diagnosis but also paves the way for
                      targeted therapeutic interventions.},
      subtyp        = {Review Article},
      keywords     = {Apoptotic Cell Clearance (Other) / Infertility (Other) /
                      Phagocytosis (Other) / Reproductive Diseases (Other) /
                      Reproductive Physiology (Other)},
      cin          = {B070},
      ddc          = {610},
      cid          = {I:(DE-He78)B070-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39631138},
      doi          = {10.1016/j.jri.2024.104413},
      url          = {https://inrepo02.dkfz.de/record/294825},
}