TY  - JOUR
AU  - Porcari, Serena
AU  - Mullish, Benjamin H
AU  - Asnicar, Francesco
AU  - Ng, Siew C
AU  - Zhao, Liping
AU  - Hansen, Richard
AU  - O'Toole, Paul W
AU  - Raes, Jeroen
AU  - Hold, Georgina
AU  - Putignani, Lorenza
AU  - Hvas, Christian Lodberg
AU  - Zeller, Georg
AU  - Koren, Omry
AU  - Tun, Hein
AU  - Valles-Colomer, Mireia
AU  - Collado, Maria Carmen
AU  - Fischer, Monika
AU  - Allegretti, Jessica
AU  - Iqbal, Tariq
AU  - Chassaing, Benoit
AU  - Keller, Josbert
AU  - Baunwall, Simon Mark
AU  - Abreu, Maria
AU  - Barbara, Giovanni
AU  - Zhang, Faming
AU  - Ponziani, Francesca Romana
AU  - Costello, Sam P
AU  - Paramsothy, Sudarshan
AU  - Kao, Dina
AU  - Kelly, Colleen
AU  - Kupcinskas, Juozas
AU  - Youngster, Ilan
AU  - Franceschi, Francesco
AU  - Khanna, Sahil
AU  - Vehreschild, Maria
AU  - Link, Alexander
AU  - De Maio, Flavio
AU  - Pasolli, Edoardo
AU  - Miguez, Aitor Blanco
AU  - Brigidi, Patrizia
AU  - Posteraro, Brunella
AU  - Scaldaferri, Franco
AU  - Stojanovic, Mirjana Rajilic
AU  - Megraud, Francis
AU  - Malfertheiner, Peter
AU  - Masucci, Luca
AU  - Arumugam, Manimozhiyan
AU  - Kaakoush, Nadeem
AU  - Segal, Eran
AU  - Bajaj, Jasmohan
AU  - Leong, Rupert
AU  - Cryan, John
AU  - Weersma, Rinse K
AU  - Knight, Robert
AU  - Guarner, Francisco
AU  - Shanahan, Fergus
AU  - Cani, Patrice D
AU  - Elinav, Eran
AU  - Sanguinetti, Maurizio
AU  - de Vos, Willem M
AU  - El-Omar, Emad
AU  - Dorè, Joel
AU  - Marchesi, Julian
AU  - Tilg, Herbert
AU  - Sokol, Harry
AU  - Segata, Nicola
AU  - Cammarota, Giovanni
AU  - Gasbarrini, Antonio
AU  - Ianiro, Gianluca
TI  - International consensus statement on microbiome testing in clinical practice.
JO  - The lancet / Gastroenterology & Hepatology
VL  - 10
IS  - 2
SN  - 2468-1253
CY  - London
PB  - Elsevier
M1  - DKFZ-2024-02557
SP  - 154-167
PY  - 2025
N1  - Volume 10, Issue 2, February 2025, Pages 154-167
AB  - There is growing interest in the potential exploitation of the gut microbiome as a diagnostic tool in medicine, but evidence supporting its clinical usefulness is scarce. An increasing number of commercial providers offer direct-to-consumer microbiome diagnostic tests without any consensus on their regulation or any proven value in clinical practice, which could result in considerable waste of individual and health-care resources and potential drawbacks in the clinical management of patients. We convened an international multidisciplinary expert panel to standardise best practices of microbiome testing for clinical implementation, including recommendations on general principles and minimum requirements for their provision, indications, pre-testing protocols, method of analyses, reporting of results, and potential clinical value. We also evaluated current knowledge gaps and future directions in this field. We aimed to establish a framework to regulate the provision of microbiome testing and minimise the use of inappropriate tests and pave the way for the evidence-based development and use of human microbiome diagnostics in clinical medicine.
LB  - PUB:(DE-HGF)16
C6  - pmid:39647502
DO  - DOI:10.1016/S2468-1253(24)00311-X
UR  - https://inrepo02.dkfz.de/record/294847
ER  -