TY  - JOUR
AU  - Mandic, Marko
AU  - Safizadeh, Fatemeh
AU  - Hoffmeister, Michael
AU  - Brenner, Hermann
TI  - Overcoming underestimation of the share of colorectal cancer cases attributable to excess weight: a population-based study.
JO  - Obesity
VL  - 33
IS  - 1
SN  - 1071-7323
CY  - Hoboken, NJ
PB  - Wiley
M1  - DKFZ-2024-02625
SP  - 156-163
PY  - 2025
N1  - #EA:C070#LA:C070# / 2025 Jan;33(1):156-163
AB  - Previous research may have underestimated the relationship between overweight/obesity and colorectal cancer (CRC) risk by overlooking important potential sources of bias.We used data from a large, population-based case-control study encompassing 7098 CRC cases and 5757 age- and sex-matched controls with comprehensive information on risk factors, including self-reported body weight. Multivariate logistic regression was used to assess the associations of BMI with CRC risk before and after considering prediagnostic weight loss, history of lower gastrointestinal endoscopy, and potentially increased CRC risk beneath the overweight threshold (BMI 25 kg/m2). Subsequently, population attributable fractions were calculated.In the standard analysis evaluating the BMI-CRC association, in which none of the three aforementioned factors was considered, the fraction of CRC cases attributable to overweight and obesity was estimated to be 11.5
LB  - PUB:(DE-HGF)16
C6  - pmid:39658513
DO  - DOI:10.1002/oby.24164
UR  - https://inrepo02.dkfz.de/record/294918
ER  -