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@ARTICLE{Mandic:294918,
      author       = {M. Mandic$^*$ and F. Safizadeh$^*$ and M. Hoffmeister$^*$
                      and H. Brenner$^*$},
      title        = {{O}vercoming underestimation of the share of colorectal
                      cancer cases attributable to excess weight: a
                      population-based study.},
      journal      = {Obesity},
      volume       = {33},
      number       = {1},
      issn         = {1071-7323},
      address      = {Hoboken, NJ},
      publisher    = {Wiley},
      reportid     = {DKFZ-2024-02625},
      pages        = {156-163},
      year         = {2025},
      note         = {#EA:C070#LA:C070# / 2025 Jan;33(1):156-163},
      abstract     = {Previous research may have underestimated the relationship
                      between overweight/obesity and colorectal cancer (CRC) risk
                      by overlooking important potential sources of bias.We used
                      data from a large, population-based case-control study
                      encompassing 7098 CRC cases and 5757 age- and sex-matched
                      controls with comprehensive information on risk factors,
                      including self-reported body weight. Multivariate logistic
                      regression was used to assess the associations of BMI with
                      CRC risk before and after considering prediagnostic weight
                      loss, history of lower gastrointestinal endoscopy, and
                      potentially increased CRC risk beneath the overweight
                      threshold (BMI 25 kg/m2). Subsequently, population
                      attributable fractions were calculated.In the standard
                      analysis evaluating the BMI-CRC association, in which none
                      of the three aforementioned factors was considered, the
                      fraction of CRC cases attributable to overweight and obesity
                      was estimated to be $11.5\%.$ This finding is consistent
                      with estimates from previous studies, which mostly did not
                      consider any of the three factors. However, when all three
                      factors were considered in the analysis, a higher BMI was
                      estimated to account for $23.4\%$ of all CRC cases.Careful
                      consideration of important sources of bias suggests that a
                      substantially larger share of the CRC burden may be
                      attributable to excess weight than previously thought.},
      cin          = {C070 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)HD01-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39658513},
      doi          = {10.1002/oby.24164},
      url          = {https://inrepo02.dkfz.de/record/294918},
}