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@ARTICLE{Koeppel:294923,
      author       = {M. Koeppel and K. Steindorf$^*$ and M. Schmidt$^*$ and F.
                      Rosenberger and J. Wiskemann},
      title        = {{V}ariability in resistance training trajectories of breast
                      cancer patients undergoing therapy.},
      journal      = {Supportive care in cancer},
      volume       = {33},
      number       = {1},
      issn         = {0941-4355},
      address      = {New York,NY},
      publisher    = {Springer},
      reportid     = {DKFZ-2024-02630},
      pages        = {12},
      year         = {2025},
      note         = {published online 10 December 2024},
      abstract     = {In resistance training (RT), the change in volume-load from
                      training sessions (TS) to TS is an indicator of training
                      progress. Resulting growth trajectories are likely to differ
                      between individuals. Understanding this variation is
                      important for exercise planning in general, but even more
                      for clinical populations. We investigated this variation in
                      breast cancer patients undergoing treatment.Data of 69
                      patients from two randomized controlled trails were
                      investigated. They conducted a 12-week RT program. We fitted
                      a quadratic Bayesian regression model to the baseline
                      standardized volume-load over the course of the
                      intervention. We allowed all parameters to vary both between
                      exercises and between individuals.We observed a positive
                      linear component of 0.093 $(95\%$ uncertainty interval (UI)
                      0.058 to 0.120) and a negative quadratic component of -
                      0.002 $(95\%$ UI -0.008 to 0.001) for the mean trajectory of
                      the change in volume-load. For the different exercises, we
                      observed a dispersion for both the linear (0.043, $95\%$ UI
                      0.018 to 0.082) and the quadratic component (0.002, $95\%$
                      UI < 0.001 to 0.004). Variation between individual appears
                      to be approximately four times larger. We also observed
                      between-exercise variation within individuals. Extrapolation
                      of the regression model indicates training progression
                      stagnates after 20.6 TS $(95\%$ UI 14.8 to 44.4).There is
                      substantial variation in RT response between breast cancer
                      patients undergoing tumor therapy and in-between exercises.
                      The non-linear trajectory indicates that training
                      progression will eventually plateau, demanding periodization
                      and timely modification.BEATE Study: NCT01106820, Date:
                      April 20, 2010; BEST Study: NCT01468766, Date: November 9,
                      2011.},
      keywords     = {Humans / Breast Neoplasms: therapy / Female / Resistance
                      Training: methods / Middle Aged / Bayes Theorem / Adult /
                      Aged / Adjuvant tumor treatment (Other) / Bayesian
                      statistics (Other) / Exercise oncology (Other) /
                      Hierarchical model (Other) / Response variability (Other)},
      cin          = {C110},
      ddc          = {610},
      cid          = {I:(DE-He78)C110-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39656317},
      doi          = {10.1007/s00520-024-09001-4},
      url          = {https://inrepo02.dkfz.de/record/294923},
}