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000295827 041__ $$aEnglish
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000295827 1001_ $$aMilenkovic, Ivan$$b0
000295827 245__ $$aEpitranscriptomic rRNA fingerprinting reveals tissue-of-origin and tumor-specific signatures.
000295827 260__ $$aNew York, NY$$bElsevier$$c2025
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000295827 500__ $$aMolecular Cell, 85(1), pp. 177–190.e7, 2025
000295827 520__ $$aMammalian ribosomal RNA (rRNA) molecules are highly abundant RNAs, decorated with over 220 rRNA modifications. Previous works have shown that some rRNA modification types can be dynamically regulated; however, how and when the mammalian rRNA modification landscape is remodeled remains largely unexplored. Here, we employ direct RNA sequencing to chart the human and mouse rRNA epitranscriptome across tissues, developmental stages, cell types, and disease. Our analyses reveal multiple rRNA sites that are differentially modified in a tissue- and/or developmental stage-specific manner, including previously unannotated modified sites. We demonstrate that rRNA modification patterns can be used for tissue and cell-type identification, which we hereby term 'epitranscriptomic fingerprinting.' We then explore rRNA modification patterns in normal-tumor matched samples from lung cancer patients, finding that epitranscriptomic fingerprinting accurately classifies clinical samples into normal and tumor groups from only 250 reads per sample, demonstrating the potential of rRNA modifications as diagnostic biomarkers.
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000295827 650_7 $$2Other$$aRNA modifications
000295827 650_7 $$2Other$$acancer
000295827 650_7 $$2Other$$aclassification
000295827 650_7 $$2Other$$adirect RNA sequencing
000295827 650_7 $$2Other$$aepitranscriptome
000295827 650_7 $$2Other$$afingerprinting
000295827 650_7 $$2Other$$ananopore
000295827 650_7 $$2Other$$apseudouridine
000295827 650_7 $$2Other$$arRNA
000295827 7001_ $$aCruciani, Sonia$$b1
000295827 7001_ $$aLlovera, Laia$$b2
000295827 7001_ $$aLucas, Morghan C$$b3
000295827 7001_ $$aMedina, Rebeca$$b4
000295827 7001_ $$0P:(DE-He78)09cd3a09acde3c9d99ac67be925b517c$$aPauli, Cornelius$$b5$$udkfz
000295827 7001_ $$0P:(DE-HGF)0$$aHeid, Daniel$$b6
000295827 7001_ $$aMuley, Thomas$$b7
000295827 7001_ $$aSchneider, Marc A$$b8
000295827 7001_ $$aKlotz, Laura V$$b9
000295827 7001_ $$aAllgäuer, Michael$$b10
000295827 7001_ $$aLattuca, Ruben$$b11
000295827 7001_ $$aLafontaine, Denis L J$$b12
000295827 7001_ $$aMüller-Tidow, Carsten$$b13
000295827 7001_ $$aNovoa, Eva Maria$$b14
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