% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@MASTERSTHESIS{Hanne:295842,
      author       = {M. Hanne$^*$},
      title        = {{S}ynthesis of {T}argeted {D}egraders and {I}nhibitors for
                      {B}ranched-{C}hain {A}mino {A}cid {A}minotransferase 1},
      school       = {University of Heidelberg},
      type         = {Masterarbeit},
      reportid     = {DKFZ-2024-02659},
      year         = {2024},
      note         = {Masterarbeit, University of Heidelberg, 2024},
      abstract     = {Branched-chain amino acid transferase 1 (BCAT1), the
                      cytosolic isozyme of BCAT, is an enzyme that catalyzes the
                      transamination reaction of branched-chain amino acids, such
                      as leucine or valine, towards α-keto acids to fuel the
                      citric acid cycle, while also being suspected of showing a
                      moonlighting function in mitosis. In the literature, a high
                      abundance of BCAT1 in a number of cancer types has been
                      reported, with BCAT1 knock-out cells showing reduced cell
                      proliferation. These findings make it a promising target in
                      medicinal chemistry, with a number of recent approaches
                      targeting the enzyme.In this thesis, a number of different
                      targeted degraders (PROTACs) and inhibitors for BCAT1 is
                      reported, with different structural modifications being
                      screened to improve activity and cell permeability. The
                      obtained inhibitors are tested for activity against BCAT1 in
                      an enzyme assay, and for cell permeability using a Caco-2
                      assay.},
      cin          = {A390},
      cid          = {I:(DE-He78)A390-20160331},
      pnm          = {311 - Zellbiologie und Tumorbiologie (POF4-311)},
      pid          = {G:(DE-HGF)POF4-311},
      typ          = {PUB:(DE-HGF)19},
      url          = {https://inrepo02.dkfz.de/record/295842},
}