%0 Journal Article
%A Liu, Aoxing
%A Genovese, Giulio
%A Zhao, Yajie
%A Pirinen, Matti
%A Zekavat, Seyedeh M
%A Kentistou, Katherine A
%A Yang, Zhiyu
%A Yu, Kai
%A Vlasschaert, Caitlyn
%A Liu, Xiaoxi
%A Brown, Derek W
%A Hudjashov, Georgi
%A Gorman, Bryan R
%A Dennis, Joe
%A Zhou, Weiyin
%A Momozawa, Yukihide
%A Pyarajan, Saiju
%A Tuzov, Valdislav
%A Pajuste, Fanny-Dhelia
%A Aavikko, Mervi
%A Sipilä, Timo P
%A Ghazal, Awaisa
%A Huang, Wen-Yi
%A Freedman, Neal D
%A Song, Lei
%A Gardner, Eugene J
%A Sankaran, Vijay G
%A Palotie, Aarno
%A Ollila, Hanna M
%A Tukiainen, Taru
%A Chanock, Stephen J
%A Mägi, Reedik
%A Natarajan, Pradeep
%A Daly, Mark J
%A Bick, Alexander
%A McCarroll, Steven A
%A Terao, Chikashi
%A Loh, Po-Ru
%A Ganna, Andrea
%A Perry, John R B
%A Machiela, Mitchell J
%T Genetic drivers and cellular selection of female mosaic X chromosome loss.
%J Nature
%V 631
%N 8019
%@ 0028-0836
%C London [u.a.]
%I Nature Publ. Group
%M DKFZ-2024-02733
%P 134 - 141
%D 2024
%X Mosaic loss of the X chromosome (mLOX) is the most common clonal somatic alteration in leukocytes of female individuals1,2, but little is known about its genetic determinants or phenotypic consequences. Here, to address this, we used data from 883,574 female participants across 8 biobanks; 12
%K Adult
%K Female
%K Humans
%K Male
%K Middle Aged
%K Alleles
%K Aneuploidy
%K Autoimmune Diseases: genetics
%K Biological Specimen Banks
%K Chromosome Segregation: genetics
%K Chromosomes, Human, X: genetics
%K Chromosomes, Human, Y: genetics
%K Clone Cells: metabolism
%K Clone Cells: pathology
%K Exome: genetics
%K F-Box Proteins: genetics
%K Genetic Predisposition to Disease: genetics
%K Germ-Line Mutation
%K Leukemia: genetics
%K Leukocytes: metabolism
%K Models, Genetic
%K Mosaicism
%K Multifactorial Inheritance: genetics
%K Mutation, Missense: genetics
%K F-Box Proteins (NLM Chemicals)
%K FBXO10 protein, human (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:38867047
%R 10.1038/s41586-024-07533-7
%U https://inrepo02.dkfz.de/record/295920