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000295958 1001_ $$0P:(DE-He78)6b2470ad968c5fe476dab8ef06e491ea$$aOtonicar, Jan$$b0$$eFirst author$$udkfz
000295958 245__ $$aHIPSD&R-seq enables scalable genomic copy number and transcriptome profiling.
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000295958 520__ $$aSingle-cell DNA sequencing (scDNA-seq) enables decoding somatic cancer variation. Existing methods are hampered by low throughput or cannot be combined with transcriptome sequencing in the same cell. We propose HIPSD&R-seq (HIgh-throughPut Single-cell Dna and Rna-seq), a scalable yet simple and accessible assay to profile low-coverage DNA and RNA in thousands of cells in parallel. Our approach builds on a modification of the 10X Genomics platform for scATAC and multiome profiling. In applications to human cell models and primary tissue, we demonstrate the feasibility to detect rare clones and we combine the assay with combinatorial indexing to profile over 17,000 cells.
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000295958 650_7 $$2Other$$aSingle Cell DNA sequencing
000295958 650_7 $$2Other$$aSingle Cell copy Number profiling
000295958 650_7 $$2Other$$aSingle Cell multiome
000295958 650_2 $$2MeSH$$aHumans
000295958 650_2 $$2MeSH$$aSingle-Cell Analysis: methods
000295958 650_2 $$2MeSH$$aGene Expression Profiling: methods
000295958 650_2 $$2MeSH$$aHigh-Throughput Nucleotide Sequencing: methods
000295958 650_2 $$2MeSH$$aGenomics: methods
000295958 650_2 $$2MeSH$$aTranscriptome
000295958 650_2 $$2MeSH$$aSequence Analysis, DNA: methods
000295958 650_2 $$2MeSH$$aSequence Analysis, RNA: methods
000295958 650_2 $$2MeSH$$aDNA Copy Number Variations
000295958 7001_ $$0P:(DE-He78)cff99e52773f68a6814c4fbdd196aa8a$$aLazareva, Olga$$b1$$eFirst author$$udkfz
000295958 7001_ $$0P:(DE-He78)697cb039ca08f3b7e5a2a52dbf020b46$$aMallm, Jan-Philipp$$b2$$eFirst author$$udkfz
000295958 7001_ $$0P:(DE-He78)1fdaffee272e57a73f861a0ea36c4079$$aSimovic-Lorenz, Milena$$b3$$udkfz
000295958 7001_ $$0P:(DE-He78)78421a888a27374f1a010a61cde7f6a7$$aPhilippos, George$$b4$$udkfz
000295958 7001_ $$0P:(DE-He78)0178c28b2dee9e8a977975ba9ff006e2$$aSant, Pooja$$b5$$udkfz
000295958 7001_ $$0P:(DE-He78)d175d4ab09be0f7c46e1563679f341c7$$aParekh, Urja$$b6$$udkfz
000295958 7001_ $$0P:(DE-He78)6268906e54e5ca1f69e966a42d92bff7$$aHammann, Linda$$b7
000295958 7001_ $$0P:(DE-He78)081d2e0ef5b433f60cc6d28496070e8a$$aLi, Albert$$b8
000295958 7001_ $$aYildiz, Umut$$b9
000295958 7001_ $$aMarttinen, Mikael$$b10
000295958 7001_ $$aZaugg, Judith$$b11
000295958 7001_ $$aNoh, Kyung Min$$b12
000295958 7001_ $$0P:(DE-He78)9aabcfee1a1fc9202398a45a63f0b1e3$$aStegle, Oliver$$b13$$eLast author$$udkfz
000295958 7001_ $$0P:(DE-He78)509fb81813c1911954da583129e8ea57$$aErnst, Aurélie$$b14$$eLast author$$udkfz
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