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@ARTICLE{Li:296014,
      author       = {H. Li$^*$ and C.-Y. Lee$^*$ and H.-J. Delecluse$^*$},
      title        = {{E}pstein-{B}arr virus lytic replication and cancer.},
      journal      = {Current opinion in virology},
      volume       = {70},
      issn         = {1879-6257},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2024-02757},
      pages        = {101438},
      year         = {2025},
      note         = {#EA:D400#LA:D400#},
      abstract     = {Epidemiological studies have provided strong evidence that
                      Epstein-Barr virus (EBV) lytic replication is linked to
                      cancer development. Evidence of abortive lytic replication
                      in some tumors and infections with recombinant viruses
                      incapable of lytic replication in animal models have
                      reinforced this view. Furthermore, multiple lytic proteins
                      have been shown to induce genetic instability, a
                      well-characterized precancerous state. In particular, lytic
                      proteins dysregulated the DNA damage response, interfered
                      with cell cycle progression, and induced the development of
                      structural genetic abnormalities. However, there is so far
                      no direct evidence from in vivo or in vitro studies that
                      lytic replication alone can induce cancer. Here, we
                      critically review the currently available evidence that EBV
                      lytic replication contributes to cancer development and
                      suggest future research directions.},
      subtyp        = {Review Article},
      cin          = {D400},
      ddc          = {610},
      cid          = {I:(DE-He78)D400-20160331},
      pnm          = {314 - Immunologie und Krebs (POF4-314)},
      pid          = {G:(DE-HGF)POF4-314},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39700641},
      doi          = {10.1016/j.coviro.2024.101438},
      url          = {https://inrepo02.dkfz.de/record/296014},
}