%0 Journal Article
%A Fabian, Alexander
%A Buergy, Daniel
%A Weykamp, Fabian
%A Hörner-Rieber, Juliane
%A Bernhardt, Denise
%A Boda-Heggemann, Judit
%A Pazos, Montserrat
%A Mehrhof, Nora
%A Kaul, David
%A Bicu, Alicia S
%A Badra, Eugenia Vlaskou
%A Rogers, Susanne
%A Janssen, Stefan
%A Hemmatazad, Hossein
%A Hintelmann, Katharina
%A Gkika, Eleni
%A Lange, Tim
%A Ferentinos, Konstantinos
%A Karle, Heiko
%A Brunner, Thomas
%A Wittig, Andrea
%A Nona-Duma, Marciana
%A Blanck, Oliver
%A Krug, David
%T Metastasis-directed stereotactic radiotherapy in patients with breast cancer: results of an international multicenter cohort study.
%J Clinical & experimental metastasis
%V 42
%N 1
%@ 0262-0898
%C Dordrecht
%I Springer Science + Business Media B.V.
%M DKFZ-2024-02760
%P 6
%D 2025
%X Metastasis-directed therapy (MDT) for oligometastatic breast cancer (≤ 5 metastases) has shown little effect in specific scenarios of randomized trials. Therefore, we aimed to assess outcomes after metastasis-directed stereotactic radiotherapy (SRT) in various clinical scenarios. We conducted an international retrospective cohort study in thirteen centers including breast cancer patients receiving SRT to any metastatic site. Outcomes included local recurrence (LR), progression-free survival (PFS), and overall survival (OS). Cumulative incidence analysis was used for LR, Kaplan-Meier estimates for PFS and OS. Covariables included patient, disease, and SRT characteristics. We performed univariable and multivariable analyses (MVA). Among 444 patients, 751 metastases were treated with SRT. Of these, 73
%K Humans
%K Female
%K Breast Neoplasms: pathology
%K Breast Neoplasms: radiotherapy
%K Breast Neoplasms: mortality
%K Breast Neoplasms: surgery
%K Retrospective Studies
%K Radiosurgery: methods
%K Middle Aged
%K Aged
%K Adult
%K Neoplasm Recurrence, Local: pathology
%K Neoplasm Recurrence, Local: radiotherapy
%K Brain Neoplasms: secondary
%K Brain Neoplasms: radiotherapy
%K Brain Neoplasms: surgery
%K Aged, 80 and over
%K Neoplasm Metastasis
%K Brain metastases (Other)
%K Breast cancer (Other)
%K Metastasis (Other)
%K Oligometastasic disease (Other)
%K Stereotactic radiotherapy (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:39708074
%2 pmc:PMC11663153
%R 10.1007/s10585-024-10326-x
%U https://inrepo02.dkfz.de/record/296017