TY  - JOUR
AU  - Fabian, Alexander
AU  - Buergy, Daniel
AU  - Weykamp, Fabian
AU  - Hörner-Rieber, Juliane
AU  - Bernhardt, Denise
AU  - Boda-Heggemann, Judit
AU  - Pazos, Montserrat
AU  - Mehrhof, Nora
AU  - Kaul, David
AU  - Bicu, Alicia S
AU  - Badra, Eugenia Vlaskou
AU  - Rogers, Susanne
AU  - Janssen, Stefan
AU  - Hemmatazad, Hossein
AU  - Hintelmann, Katharina
AU  - Gkika, Eleni
AU  - Lange, Tim
AU  - Ferentinos, Konstantinos
AU  - Karle, Heiko
AU  - Brunner, Thomas
AU  - Wittig, Andrea
AU  - Nona-Duma, Marciana
AU  - Blanck, Oliver
AU  - Krug, David
TI  - Metastasis-directed stereotactic radiotherapy in patients with breast cancer: results of an international multicenter cohort study.
JO  - Clinical & experimental metastasis
VL  - 42
IS  - 1
SN  - 0262-0898
CY  - Dordrecht
PB  - Springer Science + Business Media B.V.
M1  - DKFZ-2024-02760
SP  - 6
PY  - 2025
AB  - Metastasis-directed therapy (MDT) for oligometastatic breast cancer (≤ 5 metastases) has shown little effect in specific scenarios of randomized trials. Therefore, we aimed to assess outcomes after metastasis-directed stereotactic radiotherapy (SRT) in various clinical scenarios. We conducted an international retrospective cohort study in thirteen centers including breast cancer patients receiving SRT to any metastatic site. Outcomes included local recurrence (LR), progression-free survival (PFS), and overall survival (OS). Cumulative incidence analysis was used for LR, Kaplan-Meier estimates for PFS and OS. Covariables included patient, disease, and SRT characteristics. We performed univariable and multivariable analyses (MVA). Among 444 patients, 751 metastases were treated with SRT. Of these, 73
KW  - Humans
KW  - Female
KW  - Breast Neoplasms: pathology
KW  - Breast Neoplasms: radiotherapy
KW  - Breast Neoplasms: mortality
KW  - Breast Neoplasms: surgery
KW  - Retrospective Studies
KW  - Radiosurgery: methods
KW  - Middle Aged
KW  - Aged
KW  - Adult
KW  - Neoplasm Recurrence, Local: pathology
KW  - Neoplasm Recurrence, Local: radiotherapy
KW  - Brain Neoplasms: secondary
KW  - Brain Neoplasms: radiotherapy
KW  - Brain Neoplasms: surgery
KW  - Aged, 80 and over
KW  - Neoplasm Metastasis
KW  - Brain metastases (Other)
KW  - Breast cancer (Other)
KW  - Metastasis (Other)
KW  - Oligometastasic disease (Other)
KW  - Stereotactic radiotherapy (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:39708074
C2  - pmc:PMC11663153
DO  - DOI:10.1007/s10585-024-10326-x
UR  - https://inrepo02.dkfz.de/record/296017
ER  -