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@ARTICLE{Lamoureux:296022,
      author       = {A.-A. Lamoureux and M. J. Fisher and L. Lemelle and E.
                      Pfaff$^*$ and P. Amir-Yazdani and C. Kramm and B. De Wilde
                      and B. Kazanowska and C. Hutter and S. Pfister$^*$ and D.
                      Sturm$^*$ and D. Jones$^*$ and D. Orbach and G. Pierron and
                      S. Raskin and A. Drilon and E. L. Diamond and G. Harada and
                      M. Zapotocky and J. Zamecnik and L. Krskova and B. Ellezam
                      and A. G. Weil and D. Venne and M. Barritault and P. Leblond
                      and H. Coltin and R. Hammad and U. Tabori and C. Hawkins and
                      J. R. Hansford and D. Meyran and C. Erker and K. McFadden
                      and M. Sato and N. G. Gottardo and H. Dholaria and D. S.
                      Nørøxe and H. Goto and D. S. Ziegler and F. Y. Lin and D.
                      W. Parsons and H. Lindsay and T.-T. Wong and Y.-L. Liu and
                      K.-S. Wu and A. T. Franson and E. Hwang and A.
                      Aguilar-Bonilla and S. Cheng and C. Cacciotti and M.
                      Massimino and E. Schiavello and P. Wood and L. M. Hoffman
                      and A. Cappellano and A. Lassaletta and A. Van Damme and A.
                      Llort and N. U. Gerber and M. Spalato Ceruso and A. E.
                      Bendel and M. Skrypek and D. Hamideh and N. Mushtaq and A.
                      Walter and N. Jabado and A. Alsahlawi and J.-P. Farmer and
                      C. Coleman and S. Mueller and C. Mazewski and D. Aguilera
                      and N. J. Robison and K. O'Halloran and S. Abbou and P.
                      Berlanga and B. Geoerger and I. Øra and C. L. Moertel and
                      E. D. Razis and A. Vernadou and F. Ducray and C. Bronnimann
                      and R. Seizeur and M. Clarke and A. C. Resnick and M. Alves
                      and C. Jones and F. Doz and T. W. Laetsch and S. Perreault},
      title        = {{C}linical characteristics and outcome of central nervous
                      system tumors harboring {NTRK} gene fusions.},
      journal      = {Clinical cancer research},
      volume       = {31},
      number       = {3},
      issn         = {1078-0432},
      address      = {Philadelphia, Pa. [u.a.]},
      publisher    = {AACR},
      reportid     = {DKFZ-2024-02765},
      pages        = {561-572},
      year         = {2025},
      note         = {2025 Feb 3;31(3):561-572},
      abstract     = {TRK fusions are detected in less than $2\%$ of central
                      nervous system tumors. There are limited data on the
                      clinical course of affected patients.We conducted an
                      international retrospective cohort study of patients with
                      TRK fusion-driven CNS tumors.119 patients were identified.
                      The median age at time of diagnosis was 4.5 years. The
                      majority were reported to have a histology consistent with a
                      diagnosis of high-grade glioma (HGG) $(57.1\%)$ followed by
                      low-grade glioma (LGG) $(27.7\%).$ Pediatric patients had a
                      better prognosis with a median overall survival of 185.5
                      months compared to 24.8 months in adults (p<.0001). Patients
                      with LGG also had a better outcome when compared to HGG
                      (p=0.0012). The objective response was $68.8\%$ with
                      larotrectinib compared to $38.1\%$ for non-targeted
                      treatment.Children with LGG glioma had a favorable outcome
                      compared to adult and HGG. TRK inhibitors appear to improve
                      tumor control.},
      cin          = {B360},
      ddc          = {610},
      cid          = {I:(DE-He78)B360-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39625867},
      doi          = {10.1158/1078-0432.CCR-24-0581},
      url          = {https://inrepo02.dkfz.de/record/296022},
}