Clinical characteristics and outcome of central nervous system tumors harboring NTRK gene fusions.

Lamoureux, Audrey-Anne; Sato, Mariko; Coleman, Christina; Zapotocky, Michal; Llort, Anna; Wu, Kuo-Sheng; Farmer, Jean-Pierre; Ziegler, David S; Pfister, Stefan; Hammad, Rawan; Gerber, Nicolas U; Clarke, Matthew; Øra, Ingrid; Alves, Mélanie; Weil, Alexander G; Bendel, Anne E; Meyran, Deborah; Wood, Paul; Nørøxe, Dorte Schou; Jones, David; Mazewski, Claire; Mushtaq, Naureen; Mueller, Sabine; Lindsay, Holly; Parsons, Donald Williams; Perreault, Sébastien; Pierron, Gaëlle; Hansford, Jordan R; Hutter, Caroline; Goto, Hiroaki; Spalato Ceruso, Mariella; Kramm, Christof; Orbach, Daniel; Jabado, Nada; Cacciotti, Chantel; Robison, Nathan J; Gottardo, Nicholas G; Alsahlawi, Aysha; Resnick, Adam C; Fisher, Michael J; Ducray, François; Seizeur, Romuald; Hawkins, Cynthia; De Wilde, Bram; Skrypek, Maggie; Laetsch, Theodore W; Berlanga, Pablo; Aguilera, Dolly; Harada, Guilherme; McFadden, Kathryn; Pfaff, Elke; Lin, Frank Y; Aguilar-Bonilla, Ana; Barritault, Marc; Dholaria, Hetal; Leblond, Pierre; Vernadou, Anastasia; Wong, Tai-Tong; Franson, Andrea T; Kazanowska, Bernarda; Hoffman, Lindsey M; Hamideh, Dima; Walter, Andrew; Bronnimann, Charlotte; Krskova, Lenka; Lassaletta, Alvaro; Tabori, Uri; Ellezam, Benjamin; Diamond, Eli L; Amir-Yazdani, Pouneh; Liu, Yen-Lin; Razis, Evangelia D; Hwang, Eugene; Jones, Chris; Erker, Craig; Massimino, Maura; Abbou, Samuel; Venne, Dominic; Moertel, Christopher L; Geoerger, Birgit; Cappellano, Andréa; Coltin, Hallie; Raskin, Scott; O'Halloran, Katrina; Zamecnik, Josef; Lemelle, Lauriane; Doz, François; Schiavello, Elisabetta; Sturm, Dominik; Cheng, Sylvia; Drilon, Alexander; Van Damme, An

doi:10.1158/1078-0432.CCR-24-0581

Items
Marc 21

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024	7	_	\|a 10.1158/1078-0432.CCR-24-0581 \|2 doi
024	7	_	\|a pmid:39625867 \|2 pmid
024	7	_	\|a 1078-0432 \|2 ISSN
024	7	_	\|a 1557-3265 \|2 ISSN
024	7	_	\|a altmetric:171529367 \|2 altmetric
037	_	_	\|a DKFZ-2024-02765
041	_	_	\|a English
082	_	_	\|a 610
100	1	_	\|a Lamoureux, Audrey-Anne \|0 0009-0008-3878-8995 \|b 0
245	_	_	\|a Clinical characteristics and outcome of central nervous system tumors harboring NTRK gene fusions.
260	_	_	\|a Philadelphia, Pa. [u.a.] \|c 2025 \|b AACR
336	7	_	\|a article \|2 DRIVER
336	7	_	\|a Output Types/Journal article \|2 DataCite
336	7	_	\|a Journal Article \|b journal \|m journal \|0 PUB:(DE-HGF)16 \|s 1738595438_22142 \|2 PUB:(DE-HGF)
336	7	_	\|a ARTICLE \|2 BibTeX
336	7	_	\|a JOURNAL_ARTICLE \|2 ORCID
336	7	_	\|a Journal Article \|0 0 \|2 EndNote
500	_	_	\|a 2025 Feb 3;31(3):561-572
520	_	_	\|a TRK fusions are detected in less than 2% of central nervous system tumors. There are limited data on the clinical course of affected patients.We conducted an international retrospective cohort study of patients with TRK fusion-driven CNS tumors.119 patients were identified. The median age at time of diagnosis was 4.5 years. The majority were reported to have a histology consistent with a diagnosis of high-grade glioma (HGG) (57.1%) followed by low-grade glioma (LGG) (27.7%). Pediatric patients had a better prognosis with a median overall survival of 185.5 months compared to 24.8 months in adults (p<.0001). Patients with LGG also had a better outcome when compared to HGG (p=0.0012). The objective response was 68.8% with larotrectinib compared to 38.1% for non-targeted treatment.Children with LGG glioma had a favorable outcome compared to adult and HGG. TRK inhibitors appear to improve tumor control.
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Marc 21

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