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@ARTICLE{Fotopoulou:296057,
      author       = {F. Fotopoulou$^*$ and E. Rodriguez-Correa$^*$ and C.
                      Dussiau$^*$ and M. Milsom$^*$},
      title        = {{R}econsidering the usual suspects in age-related
                      hematologic disorders: is stem cell dysfunction a root cause
                      of aging?},
      journal      = {Experimental hematology},
      volume       = {143},
      issn         = {0531-5573},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DKFZ-2025-00005},
      pages        = {104698},
      year         = {2025},
      note         = {#EA:A012#LA:A012# / Volume 143, March 2025, 104698},
      abstract     = {Aging exerts a profound impact on the hematopoietic system,
                      leading to increased susceptibility to infections,
                      autoimmune diseases, chronic inflammation, anemia,
                      thrombotic events, and hematologic malignancies. Within the
                      field of experimental hematology, the functional decline of
                      hematopoietic stem cells (HSCs) is often regarded as a
                      primary driver of age-related hematologic conditions.
                      However, aging is clearly a complex multifaceted process
                      involving not only HSCs but also mature blood cells and
                      their interactions with other tissues. This review
                      reappraises an HSC-centric view of hematopoietic aging by
                      exploring how the entire hematopoietic hierarchy, from stem
                      cells to mature cells, contributes to age-related disorders.
                      It highlights the decline of both innate and adaptive
                      immunity, leading to increased susceptibility to infections
                      and cancer, and the rise of autoimmunity as peripheral
                      immune cells undergo aging-induced changes. It explores the
                      concept of 'inflammaging,' where persistent, low-grade
                      inflammation driven by old immune cells creates a cycle of
                      tissue damage and disease. Additionally, this review delves
                      into the roles of inflammation and homeostatic regulation in
                      age-related conditions such as thrombotic events and anemia,
                      arguing that these issues arise from broader dysfunctions
                      rather than stemming from HSC functional attrition alone. In
                      summary, this review highlights the importance of taking a
                      holistic approach to studying hematopoietic aging and its
                      related pathologies. By looking beyond just stem cells and
                      considering the full spectrum of age-associated changes, one
                      can better capture the complexity of aging and attempt to
                      develop preventative or rejuvenative strategies that better
                      target multiple facets of this process.},
      subtyp        = {Review Article},
      keywords     = {CHIP (Other) / HSC (Other) / Hematopoietic stem cells
                      (Other) / Inflammation (Other) / aging (Other) / anemia
                      (Other) / clonal hematopoiesis (Other) / immune compromised
                      (Other) / inflammaging (Other) / myeloid bias (Other)},
      cin          = {A012},
      ddc          = {610},
      cid          = {I:(DE-He78)A012-20160331},
      pnm          = {311 - Zellbiologie und Tumorbiologie (POF4-311)},
      pid          = {G:(DE-HGF)POF4-311},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39725143},
      doi          = {10.1016/j.exphem.2024.104698},
      url          = {https://inrepo02.dkfz.de/record/296057},
}