guest ::
| Home > Publications database > Reconsidering the usual suspects in age-related hematologic disorders: is stem cell dysfunction a root cause of aging? > print |
| Home > Publications database > Reconsidering the usual suspects in age-related hematologic disorders: is stem cell dysfunction a root cause of aging? > print |
| 001 | 296057 | ||
| 005 | 20250204095609.0 | ||
| 024 | 7 | _ | |a 10.1016/j.exphem.2024.104698 |2 doi |
| 024 | 7 | _ | |a pmid:39725143 |2 pmid |
| 024 | 7 | _ | |a 0531-5573 |2 ISSN |
| 024 | 7 | _ | |a 0301-472X |2 ISSN |
| 024 | 7 | _ | |a 1873-2399 |2 ISSN |
| 024 | 7 | _ | |a altmetric:172542008 |2 altmetric |
| 037 | _ | _ | |a DKFZ-2025-00005 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Fotopoulou, Foteini |0 P:(DE-He78)4bad99a2fb907a4eef4ca80c714fdc7d |b 0 |e First author |u dkfz |
| 245 | _ | _ | |a Reconsidering the usual suspects in age-related hematologic disorders: is stem cell dysfunction a root cause of aging? |
| 260 | _ | _ | |a Amsterdam [u.a.] |c 2025 |b Elsevier Science |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1738659328_16090 |2 PUB:(DE-HGF) |x Review Article |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 500 | _ | _ | |a #EA:A012#LA:A012# / Volume 143, March 2025, 104698 |
| 520 | _ | _ | |a Aging exerts a profound impact on the hematopoietic system, leading to increased susceptibility to infections, autoimmune diseases, chronic inflammation, anemia, thrombotic events, and hematologic malignancies. Within the field of experimental hematology, the functional decline of hematopoietic stem cells (HSCs) is often regarded as a primary driver of age-related hematologic conditions. However, aging is clearly a complex multifaceted process involving not only HSCs but also mature blood cells and their interactions with other tissues. This review reappraises an HSC-centric view of hematopoietic aging by exploring how the entire hematopoietic hierarchy, from stem cells to mature cells, contributes to age-related disorders. It highlights the decline of both innate and adaptive immunity, leading to increased susceptibility to infections and cancer, and the rise of autoimmunity as peripheral immune cells undergo aging-induced changes. It explores the concept of 'inflammaging,' where persistent, low-grade inflammation driven by old immune cells creates a cycle of tissue damage and disease. Additionally, this review delves into the roles of inflammation and homeostatic regulation in age-related conditions such as thrombotic events and anemia, arguing that these issues arise from broader dysfunctions rather than stemming from HSC functional attrition alone. In summary, this review highlights the importance of taking a holistic approach to studying hematopoietic aging and its related pathologies. By looking beyond just stem cells and considering the full spectrum of age-associated changes, one can better capture the complexity of aging and attempt to develop preventative or rejuvenative strategies that better target multiple facets of this process. |
| 536 | _ | _ | |a 311 - Zellbiologie und Tumorbiologie (POF4-311) |0 G:(DE-HGF)POF4-311 |c POF4-311 |f POF IV |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, , Journals: inrepo02.dkfz.de |
| 650 | _ | 7 | |a CHIP |2 Other |
| 650 | _ | 7 | |a HSC |2 Other |
| 650 | _ | 7 | |a Hematopoietic stem cells |2 Other |
| 650 | _ | 7 | |a Inflammation |2 Other |
| 650 | _ | 7 | |a aging |2 Other |
| 650 | _ | 7 | |a anemia |2 Other |
| 650 | _ | 7 | |a clonal hematopoiesis |2 Other |
| 650 | _ | 7 | |a immune compromised |2 Other |
| 650 | _ | 7 | |a inflammaging |2 Other |
| 650 | _ | 7 | |a myeloid bias |2 Other |
| 700 | 1 | _ | |a Rodriguez-Correa, Esther |0 P:(DE-HGF)0 |b 1 |
| 700 | 1 | _ | |a Dussiau, Charles |0 P:(DE-He78)b453d9586e1af7e7ce5adf714c7e58f8 |b 2 |u dkfz |
| 700 | 1 | _ | |a Milsom, Michael |0 P:(DE-He78)7b613cadb8c16ce178713e15b85d982c |b 3 |e Last author |u dkfz |
| 773 | _ | _ | |a 10.1016/j.exphem.2024.104698 |g p. 104698 - |0 PERI:(DE-600)2005403-8 |p 104698 |t Experimental hematology |v 143 |y 2025 |x 0531-5573 |
| 909 | C | O | |p VDB |o oai:inrepo02.dkfz.de:296057 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 0 |6 P:(DE-He78)4bad99a2fb907a4eef4ca80c714fdc7d |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 1 |6 P:(DE-HGF)0 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 2 |6 P:(DE-He78)b453d9586e1af7e7ce5adf714c7e58f8 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 3 |6 P:(DE-He78)7b613cadb8c16ce178713e15b85d982c |
| 913 | 1 | _ | |a DE-HGF |b Gesundheit |l Krebsforschung |1 G:(DE-HGF)POF4-310 |0 G:(DE-HGF)POF4-311 |3 G:(DE-HGF)POF4 |2 G:(DE-HGF)POF4-300 |4 G:(DE-HGF)POF |v Zellbiologie und Tumorbiologie |x 0 |
| 914 | 1 | _ | |y 2024 |
| 915 | _ | _ | |a Nationallizenz |0 StatID:(DE-HGF)0420 |2 StatID |d 2023-08-23 |w ger |
| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b EXP HEMATOL : 2022 |d 2023-08-23 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0200 |2 StatID |b SCOPUS |d 2023-08-23 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline |d 2023-08-23 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0600 |2 StatID |b Ebsco Academic Search |d 2023-08-23 |
| 915 | _ | _ | |a Peer Review |0 StatID:(DE-HGF)0030 |2 StatID |b ASC |d 2023-08-23 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0199 |2 StatID |b Clarivate Analytics Master Journal List |d 2023-08-23 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1050 |2 StatID |b BIOSIS Previews |d 2023-08-23 |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0113 |2 StatID |b Science Citation Index Expanded |d 2023-08-23 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0150 |2 StatID |b Web of Science Core Collection |d 2023-08-23 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1030 |2 StatID |b Current Contents - Life Sciences |d 2023-08-23 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1190 |2 StatID |b Biological Abstracts |d 2023-08-23 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0160 |2 StatID |b Essential Science Indicators |d 2023-08-23 |
| 915 | _ | _ | |a IF < 5 |0 StatID:(DE-HGF)9900 |2 StatID |d 2023-08-23 |
| 920 | 2 | _ | |0 I:(DE-He78)A012-20160331 |k A012 |l A012 Experimentelle Hämatologie |x 0 |
| 920 | 1 | _ | |0 I:(DE-He78)A012-20160331 |k A012 |l A012 Experimentelle Hämatologie |x 0 |
| 920 | 0 | _ | |0 I:(DE-He78)A012-20160331 |k A012 |l A012 Experimentelle Hämatologie |x 0 |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a I:(DE-He78)A012-20160331 |
| 980 | _ | _ | |a UNRESTRICTED |
| Library | Collection | CLSMajor | CLSMinor | Language | Author |
|---|