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000296166 1001_ $$aGöpel, Siri$$b0
000296166 245__ $$aDrivers of extended spectrum β-lactamase (ESBL)-producing Enterobacterales colonization among residents of long-term health care facilities: a European multicentric prospective cohort study.
000296166 260__ $$aKidlington [u.a.]$$bElsevier$$c2025
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000296166 520__ $$aESBL-producing Enterobacterales (ESBL-PE) are highly prevalent in long-term healthcare (LTCF) settings. In order to estimate the acquisition rate of ESBL-producing Escherichia coli and Klebsiella pneumoniae in LTCF settings and identify clinical and environmental risk factors, a multicentric, prospective cohort study was conducted in six LTCFs in Germany, France, Spain and the Netherlands.Longitudinal screening of residents was performed over 32 weeks, collecting epidemiological and clinical data and environmental samples. The primary outcome was rate of new acquisition of ESBL-PE among LTCF residents. Molecular epidemiology was studied using whole genome sequencing and risk factor analyses using logistic and Poisson regression models.299 residents provided 1958 samples during follow-up. Prevalence of ESBL-PE colonization at baseline was 16.4%, incidence rate of acquisition was 0.79 per 1000 resident-days, both with high variability among centres. Age ≥80 years, vascular disease, and antibiotic consumption within one year were risk factors for baseline colonization. Lack of hand sanitizers and low nurse to resident ratio were associated with colonization. Presence of medical devices was associated with risk of acquisition. Vascular disease, hemiplegia, antibiotic consumption, and non-availability of private bathrooms were associated with multiple ST carriage. Prevalence of ESBL-PE among environmental samples was 2%, exclusively in centres with high prevalence among residents. Genetic analysis showed a high prevalence of ST10 E. coli and ST405 K. pneumoniae at two study sites.Infection prevention including availability of hand sanitizers, the number of nurses per resident, and antimicrobial stewardship interventions constitute important measures to control ESBL-PE in LTCFs. Genome-based surveillance could guide targeted interventions.
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000296166 650_7 $$2Other$$aESBL producing Enterobacterales
000296166 650_7 $$2Other$$aacquisition
000296166 650_7 $$2Other$$acolonization
000296166 650_7 $$2Other$$along-term care facility
000296166 650_7 $$2Other$$amolecular epidemiology
000296166 7001_ $$aGuther, Julia$$b1
000296166 7001_ $$aGladstone, Beryl Primrose$$b2
000296166 7001_ $$aConzelmann, Nadine$$b3
000296166 7001_ $$aBunk, Stefanie$$b4
000296166 7001_ $$0P:(DE-He78)9c4af0f5ceb3a2072b3736274eadf20e$$aTerzer, Tobias$$b5
000296166 7001_ $$aVerschuuren, Tess D$$b6
000296166 7001_ $$aMartak, Daniel$$b7
000296166 7001_ $$aSalamanca, Elena$$b8
000296166 7001_ $$aAutenrieth, Ingo B$$b9
000296166 7001_ $$agroup, MODERN WP1 study$$b10$$eCollaboration Author
000296166 7001_ $$aPeter, Silke$$b11
000296166 7001_ $$aKluytmans, Jan A J W$$b12
000296166 7001_ $$aHocquet, Didier$$b13
000296166 7001_ $$aRodriguez-Baño, Jesus$$b14
000296166 7001_ $$aTacconelli, Evelina$$b15
000296166 7001_ $$aEisenbeis, Simone$$b16$$eContributor
000296166 7001_ $$aHölzl, Florian$$b17$$eContributor
000296166 7001_ $$aPascual, Alvaro$$b18$$eContributor
000296166 7001_ $$aMedina, Rocío$$b19$$eContributor
000296166 7001_ $$aFluit, Ad$$b20$$eContributor
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