TY  - JOUR
AU  - Göpel, Siri
AU  - Guther, Julia
AU  - Gladstone, Beryl Primrose
AU  - Conzelmann, Nadine
AU  - Bunk, Stefanie
AU  - Terzer, Tobias
AU  - Verschuuren, Tess D
AU  - Martak, Daniel
AU  - Salamanca, Elena
AU  - Autenrieth, Ingo B
AU  - Peter, Silke
AU  - Kluytmans, Jan A J W
AU  - Hocquet, Didier
AU  - Rodriguez-Baño, Jesus
AU  - Tacconelli, Evelina
TI  - Drivers of extended spectrum β-lactamase (ESBL)-producing Enterobacterales colonization among residents of long-term health care facilities: a European multicentric prospective cohort study.
JO  - The journal of hospital infection
VL  - 157
SN  - 0195-6701
CY  - Kidlington [u.a.]
PB  - Elsevier
M1  - DKFZ-2025-00093
SP  - 67-74
PY  - 2025
N1  - 2025 Jan 7:157:67-74
AB  - ESBL-producing Enterobacterales (ESBL-PE) are highly prevalent in long-term healthcare (LTCF) settings. In order to estimate the acquisition rate of ESBL-producing Escherichia coli and Klebsiella pneumoniae in LTCF settings and identify clinical and environmental risk factors, a multicentric, prospective cohort study was conducted in six LTCFs in Germany, France, Spain and the Netherlands.Longitudinal screening of residents was performed over 32 weeks, collecting epidemiological and clinical data and environmental samples. The primary outcome was rate of new acquisition of ESBL-PE among LTCF residents. Molecular epidemiology was studied using whole genome sequencing and risk factor analyses using logistic and Poisson regression models.299 residents provided 1958 samples during follow-up. Prevalence of ESBL-PE colonization at baseline was 16.4
KW  - ESBL producing Enterobacterales (Other)
KW  - acquisition (Other)
KW  - colonization (Other)
KW  - long-term care facility (Other)
KW  - molecular epidemiology (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:39788455
DO  - DOI:10.1016/j.jhin.2024.12.010
UR  - https://inrepo02.dkfz.de/record/296166
ER  -