%0 Journal Article
%A Blickle, Patricia
%A Schmidt, Martina
%A Steindorf, Karen
%T Pretreatment Fatigue in Breast Cancer Patients: Comparison With Healthy Controls and Associations With Biopsychosocial Variables.
%J Cancer medicine
%V 14
%N 1
%@ 2045-7634
%C Hoboken, NJ
%I Wiley
%M DKFZ-2025-00099
%P e70404
%D 2025
%Z #EA:C110#LA:C110#
%X Cancer-related fatigue is one of the most common burdens of cancer patients. To date, most studies focused on fatigue during or after treatment. However, investigation of pretreatment fatigue is crucial to identify causal or risk factors other than cancer therapy and to enable timely fatigue management.Two hundred and thirty-two breast cancer patients (mean age = 55.6) and 41 healthy participants (mean age = 49.3) were recruited via the National Center for Tumor Diseases (NCT) Heidelberg. Patient-reported outcomes were assessed with the EORTC QLQ-FA12 for fatigue, the EORTC QLQ-C30 for functioning, the STAI for anxiety, the CESD-R for depression and the PSQI for sleep disturbance. Descriptive analyses and logistic regression models were performed using baseline data before start of cancer treatment. The thresholds of clinical importance (TCI) were applied to test for clinically relevant fatigue.Compared to the healthy participants, patients scored significantly higher in physical, emotional, and total fatigue, in depression, in global health status and in all functioning scales except cognitive function (all p < 0.01). 48.7
%K Humans
%K Female
%K Fatigue: etiology
%K Fatigue: psychology
%K Breast Neoplasms: psychology
%K Breast Neoplasms: complications
%K Middle Aged
%K Case-Control Studies
%K Adult
%K Aged
%K Quality of Life
%K Depression: etiology
%K Depression: psychology
%K Anxiety: psychology
%K Anxiety: etiology
%K Risk Factors
%K Patient Reported Outcome Measures
%K Surveys and Questionnaires
%K breast cancer patients (Other)
%K cancer (Other)
%K cancer‐related fatigue (Other)
%K oncology (Other)
%K patient‐reported outcomes (Other)
%K pretreatment fatigue (Other)
%K psychological factors (Other)
%K psycho‐oncology (Other)
%K quality of life (Other)
%K supportive care (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:39781572
%2 pmc:PMC11712150
%R 10.1002/cam4.70404
%U https://inrepo02.dkfz.de/record/296172