TY  - JOUR
AU  - Blickle, Patricia
AU  - Schmidt, Martina
AU  - Steindorf, Karen
TI  - Pretreatment Fatigue in Breast Cancer Patients: Comparison With Healthy Controls and Associations With Biopsychosocial Variables.
JO  - Cancer medicine
VL  - 14
IS  - 1
SN  - 2045-7634
CY  - Hoboken, NJ
PB  - Wiley
M1  - DKFZ-2025-00099
SP  - e70404
PY  - 2025
N1  - #EA:C110#LA:C110#
AB  - Cancer-related fatigue is one of the most common burdens of cancer patients. To date, most studies focused on fatigue during or after treatment. However, investigation of pretreatment fatigue is crucial to identify causal or risk factors other than cancer therapy and to enable timely fatigue management.Two hundred and thirty-two breast cancer patients (mean age = 55.6) and 41 healthy participants (mean age = 49.3) were recruited via the National Center for Tumor Diseases (NCT) Heidelberg. Patient-reported outcomes were assessed with the EORTC QLQ-FA12 for fatigue, the EORTC QLQ-C30 for functioning, the STAI for anxiety, the CESD-R for depression and the PSQI for sleep disturbance. Descriptive analyses and logistic regression models were performed using baseline data before start of cancer treatment. The thresholds of clinical importance (TCI) were applied to test for clinically relevant fatigue.Compared to the healthy participants, patients scored significantly higher in physical, emotional, and total fatigue, in depression, in global health status and in all functioning scales except cognitive function (all p < 0.01). 48.7
KW  - Humans
KW  - Female
KW  - Fatigue: etiology
KW  - Fatigue: psychology
KW  - Breast Neoplasms: psychology
KW  - Breast Neoplasms: complications
KW  - Middle Aged
KW  - Case-Control Studies
KW  - Adult
KW  - Aged
KW  - Quality of Life
KW  - Depression: etiology
KW  - Depression: psychology
KW  - Anxiety: psychology
KW  - Anxiety: etiology
KW  - Risk Factors
KW  - Patient Reported Outcome Measures
KW  - Surveys and Questionnaires
KW  - breast cancer patients (Other)
KW  - cancer (Other)
KW  - cancer‐related fatigue (Other)
KW  - oncology (Other)
KW  - patient‐reported outcomes (Other)
KW  - pretreatment fatigue (Other)
KW  - psychological factors (Other)
KW  - psycho‐oncology (Other)
KW  - quality of life (Other)
KW  - supportive care (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:39781572
C2  - pmc:PMC11712150
DO  - DOI:10.1002/cam4.70404
UR  - https://inrepo02.dkfz.de/record/296172
ER  -