%0 Journal Article
%A Hu, Yuqing
%A Kharazmi, Elhamalsadat
%A Liang, Qunfeng
%A Sundquist, Kristina
%A Sundquist, Jan
%A Fallah, Mahdi
%T Risk of colorectal cancer associated with frequency of colorectal polyp diagnosis in relatives.
%J Gastroenterology
%V 168
%N 5
%@ 0016-5085
%C Philadelphia, Pa. [u.a.]
%I Saunders
%M DKFZ-2025-00119
%P 931-938.e5
%D 2025
%Z #EA:C120#LA:C120# / Volume 168, Issue 5, May 2025, Pages 931-938.e5
%X We aimed to evaluate the association of frequency of polyp diagnosis in relatives with the risk of overall and early-onset colorectal cancer (CRC).We leveraged data from nationwide Swedish family cancer datasets (1964-2018) to calculate standardized incidence ratios (SIRs) for individuals with a family history of polyp by frequency of polyp diagnosis in family members.We followed up 11,676,043 individuals for up to 54 years. Compared with the risk in individuals without a family history of colorectal tumor (N=142,234), the risk of overall CRC was 1.4-fold in those with 1 FDR with one-time polyp diagnosis [95
%K Cancer prevention (Other)
%K Cancer screening (Other)
%K Colonoscopy (Other)
%K Colorectal cancer (Other)
%K Colorectal polyp (Other)
%K Family history (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:39800079
%R 10.1053/j.gastro.2024.12.030
%U https://inrepo02.dkfz.de/record/296206