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000296206 1001_ $$0P:(DE-He78)d59be7ca3c039f32929e64c64ace25d9$$aHu, Yuqing$$b0$$eFirst author$$udkfz
000296206 245__ $$aRisk of colorectal cancer associated with frequency of colorectal polyp diagnosis in relatives.
000296206 260__ $$aPhiladelphia, Pa. [u.a.]$$bSaunders$$c2025
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000296206 500__ $$a#EA:C120#LA:C120# / Volume 168, Issue 5, May 2025, Pages 931-938.e5
000296206 520__ $$aWe aimed to evaluate the association of frequency of polyp diagnosis in relatives with the risk of overall and early-onset colorectal cancer (CRC).We leveraged data from nationwide Swedish family cancer datasets (1964-2018) to calculate standardized incidence ratios (SIRs) for individuals with a family history of polyp by frequency of polyp diagnosis in family members.We followed up 11,676,043 individuals for up to 54 years. Compared with the risk in individuals without a family history of colorectal tumor (N=142,234), the risk of overall CRC was 1.4-fold in those with 1 FDR with one-time polyp diagnosis [95%CI=1.3-1.4, N=11,035; early-onset SIR: 1.4 (1.3-1.5), N=742]. The risk was significantly higher in individuals with 1 FDR with ≥2 times (frequent) polyp diagnoses [overall CRC: 1.8 (1.8-1.9); early-onset CRC=2.3 (2.0-2.6)]. A rather similar risk was observed for individuals with ≥2 FDRs with one-time polyp diagnosis [overall CRC: 1.9 (1.7-2.1); early-onset CRC: 2.2 (1.5-2.9)]. Individuals with ≥2 FDRs with frequent polyp diagnoses had a 2.4-fold overall risk (2.2-2.7) and a 3.9-fold early-onset risk (2.8-5.3). Younger age at polyp diagnosis in FDRs was associated with an increased risk of CRC. A family history of polyp in second-degree relatives was important only when there were frequent diagnoses of polyp.A higher frequency of colorectal polyp diagnosis in relatives is associated with a greater risk of CRC, especially early-onset CRC. This risk is independent of number of affected relatives or youngest age at polyp diagnosis. These findings underscore the need for more personalized CRC screening strategies that are tailored to individuals with a family history of polyp.
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000296206 650_7 $$2Other$$aCancer prevention
000296206 650_7 $$2Other$$aCancer screening
000296206 650_7 $$2Other$$aColonoscopy
000296206 650_7 $$2Other$$aColorectal cancer
000296206 650_7 $$2Other$$aColorectal polyp
000296206 650_7 $$2Other$$aFamily history
000296206 7001_ $$0P:(DE-He78)e56510c7dedbff7a279ad76dad80eeda$$aKharazmi, Elhamalsadat$$b1
000296206 7001_ $$0P:(DE-He78)59bc83ea3f8c2a5ef6118233f87b5e68$$aLiang, Qunfeng$$b2$$udkfz
000296206 7001_ $$aSundquist, Kristina$$b3
000296206 7001_ $$aSundquist, Jan$$b4
000296206 7001_ $$0P:(DE-He78)b510b884502b619724039bf33fdae68a$$aFallah, Mahdi$$b5$$eLast author$$udkfz
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