TY  - JOUR
AU  - Hu, Yuqing
AU  - Kharazmi, Elhamalsadat
AU  - Liang, Qunfeng
AU  - Sundquist, Kristina
AU  - Sundquist, Jan
AU  - Fallah, Mahdi
TI  - Risk of colorectal cancer associated with frequency of colorectal polyp diagnosis in relatives.
JO  - Gastroenterology
VL  - 168
IS  - 5
SN  - 0016-5085
CY  - Philadelphia, Pa. [u.a.]
PB  - Saunders
M1  - DKFZ-2025-00119
SP  - 931-938.e5
PY  - 2025
N1  - #EA:C120#LA:C120# / Volume 168, Issue 5, May 2025, Pages 931-938.e5
AB  - We aimed to evaluate the association of frequency of polyp diagnosis in relatives with the risk of overall and early-onset colorectal cancer (CRC).We leveraged data from nationwide Swedish family cancer datasets (1964-2018) to calculate standardized incidence ratios (SIRs) for individuals with a family history of polyp by frequency of polyp diagnosis in family members.We followed up 11,676,043 individuals for up to 54 years. Compared with the risk in individuals without a family history of colorectal tumor (N=142,234), the risk of overall CRC was 1.4-fold in those with 1 FDR with one-time polyp diagnosis [95
KW  - Cancer prevention (Other)
KW  - Cancer screening (Other)
KW  - Colonoscopy (Other)
KW  - Colorectal cancer (Other)
KW  - Colorectal polyp (Other)
KW  - Family history (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:39800079
DO  - DOI:10.1053/j.gastro.2024.12.030
UR  - https://inrepo02.dkfz.de/record/296206
ER  -