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@ARTICLE{Hu:296206,
      author       = {Y. Hu$^*$ and E. Kharazmi$^*$ and Q. Liang$^*$ and K.
                      Sundquist and J. Sundquist and M. Fallah$^*$},
      title        = {{R}isk of colorectal cancer associated with frequency of
                      colorectal polyp diagnosis in relatives.},
      journal      = {Gastroenterology},
      volume       = {168},
      number       = {5},
      issn         = {0016-5085},
      address      = {Philadelphia, Pa. [u.a.]},
      publisher    = {Saunders},
      reportid     = {DKFZ-2025-00119},
      pages        = {931-938.e5},
      year         = {2025},
      note         = {#EA:C120#LA:C120# / Volume 168, Issue 5, May 2025, Pages
                      931-938.e5},
      abstract     = {We aimed to evaluate the association of frequency of polyp
                      diagnosis in relatives with the risk of overall and
                      early-onset colorectal cancer (CRC).We leveraged data from
                      nationwide Swedish family cancer datasets (1964-2018) to
                      calculate standardized incidence ratios (SIRs) for
                      individuals with a family history of polyp by frequency of
                      polyp diagnosis in family members.We followed up 11,676,043
                      individuals for up to 54 years. Compared with the risk in
                      individuals without a family history of colorectal tumor
                      (N=142,234), the risk of overall CRC was 1.4-fold in those
                      with 1 FDR with one-time polyp diagnosis $[95\%CI=1.3-1.4,$
                      N=11,035; early-onset SIR: 1.4 (1.3-1.5), N=742]. The risk
                      was significantly higher in individuals with 1 FDR with ≥2
                      times (frequent) polyp diagnoses [overall CRC: 1.8
                      (1.8-1.9); early-onset CRC=2.3 (2.0-2.6)]. A rather similar
                      risk was observed for individuals with ≥2 FDRs with
                      one-time polyp diagnosis [overall CRC: 1.9 (1.7-2.1);
                      early-onset CRC: 2.2 (1.5-2.9)]. Individuals with ≥2 FDRs
                      with frequent polyp diagnoses had a 2.4-fold overall risk
                      (2.2-2.7) and a 3.9-fold early-onset risk (2.8-5.3). Younger
                      age at polyp diagnosis in FDRs was associated with an
                      increased risk of CRC. A family history of polyp in
                      second-degree relatives was important only when there were
                      frequent diagnoses of polyp.A higher frequency of colorectal
                      polyp diagnosis in relatives is associated with a greater
                      risk of CRC, especially early-onset CRC. This risk is
                      independent of number of affected relatives or youngest age
                      at polyp diagnosis. These findings underscore the need for
                      more personalized CRC screening strategies that are tailored
                      to individuals with a family history of polyp.},
      keywords     = {Cancer prevention (Other) / Cancer screening (Other) /
                      Colonoscopy (Other) / Colorectal cancer (Other) / Colorectal
                      polyp (Other) / Family history (Other)},
      cin          = {C120},
      ddc          = {610},
      cid          = {I:(DE-He78)C120-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39800079},
      doi          = {10.1053/j.gastro.2024.12.030},
      url          = {https://inrepo02.dkfz.de/record/296206},
}