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@ARTICLE{Zhan:297961,
      author       = {T. Zhan and J. Betge$^*$ and N. Schulte and L. Dreikhausen
                      and M. Hirth and M. Li and P. Weidner and A. Leipertz and A.
                      Teufel and M. P. Ebert},
      title        = {{D}igestive cancers: mechanisms, therapeutics and
                      management.},
      journal      = {Signal transduction and targeted therapy},
      volume       = {10},
      number       = {1},
      issn         = {2095-9907},
      address      = {London},
      publisher    = {Macmillan Publishers, part of Springer Nature},
      reportid     = {DKFZ-2025-00138},
      pages        = {24},
      year         = {2025},
      note         = {#EA:B440#},
      abstract     = {Cancers of the digestive system are major contributors to
                      global cancer-associated morbidity and mortality, accounting
                      for $35\%$ of annual cases of cancer deaths. The etiologies,
                      molecular features, and therapeutic management of these
                      cancer entities are highly heterogeneous and complex. Over
                      the last decade, genomic and functional studies have
                      provided unprecedented insights into the biology of
                      digestive cancers, identifying genetic drivers of tumor
                      progression and key interaction points of tumor cells with
                      the immune system. This knowledge is continuously translated
                      into novel treatment concepts and targets, which are
                      dynamically reshaping the therapeutic landscape of these
                      tumors. In this review, we provide a concise overview of the
                      etiology and molecular pathology of the six most common
                      cancers of the digestive system, including esophageal,
                      gastric, biliary tract, pancreatic, hepatocellular, and
                      colorectal cancers. We comprehensively describe the current
                      stage-dependent pharmacological management of these
                      malignancies, including chemo-, targeted, and immunotherapy.
                      For each cancer entity, we provide an overview of recent
                      therapeutic advancements and research progress. Finally, we
                      describe how novel insights into tumor heterogeneity and
                      immune evasion deepen our understanding of therapy
                      resistance and provide an outlook on innovative therapeutic
                      strategies that will shape the future management of
                      digestive cancers, including CAR-T cell therapy, novel
                      antibody-drug conjugates and targeted therapies.},
      subtyp        = {Review Article},
      keywords     = {Humans / Immunotherapy / Digestive System Neoplasms:
                      therapy / Digestive System Neoplasms: genetics / Digestive
                      System Neoplasms: pathology / Digestive System Neoplasms:
                      immunology},
      cin          = {B440},
      ddc          = {610},
      cid          = {I:(DE-He78)B440-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39809756},
      pmc          = {pmc:PMC11733248},
      doi          = {10.1038/s41392-024-02097-4},
      url          = {https://inrepo02.dkfz.de/record/297961},
}