guest ::
| Home > Publications database > Digestive cancers: mechanisms, therapeutics and management. > print |
| 001 | 297961 | ||
| 005 | 20250117163316.0 | ||
| 024 | 7 | _ | |a 10.1038/s41392-024-02097-4 |2 doi |
| 024 | 7 | _ | |a pmid:39809756 |2 pmid |
| 024 | 7 | _ | |a pmc:PMC11733248 |2 pmc |
| 024 | 7 | _ | |a 2095-9907 |2 ISSN |
| 024 | 7 | _ | |a 2059-3635 |2 ISSN |
| 037 | _ | _ | |a DKFZ-2025-00138 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Zhan, Tianzuo |b 0 |
| 245 | _ | _ | |a Digestive cancers: mechanisms, therapeutics and management. |
| 260 | _ | _ | |a London |c 2025 |b Macmillan Publishers, part of Springer Nature |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1737116788_3882 |2 PUB:(DE-HGF) |x Review Article |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 500 | _ | _ | |a #EA:B440# |
| 520 | _ | _ | |a Cancers of the digestive system are major contributors to global cancer-associated morbidity and mortality, accounting for 35% of annual cases of cancer deaths. The etiologies, molecular features, and therapeutic management of these cancer entities are highly heterogeneous and complex. Over the last decade, genomic and functional studies have provided unprecedented insights into the biology of digestive cancers, identifying genetic drivers of tumor progression and key interaction points of tumor cells with the immune system. This knowledge is continuously translated into novel treatment concepts and targets, which are dynamically reshaping the therapeutic landscape of these tumors. In this review, we provide a concise overview of the etiology and molecular pathology of the six most common cancers of the digestive system, including esophageal, gastric, biliary tract, pancreatic, hepatocellular, and colorectal cancers. We comprehensively describe the current stage-dependent pharmacological management of these malignancies, including chemo-, targeted, and immunotherapy. For each cancer entity, we provide an overview of recent therapeutic advancements and research progress. Finally, we describe how novel insights into tumor heterogeneity and immune evasion deepen our understanding of therapy resistance and provide an outlook on innovative therapeutic strategies that will shape the future management of digestive cancers, including CAR-T cell therapy, novel antibody-drug conjugates and targeted therapies. |
| 536 | _ | _ | |a 312 - Funktionelle und strukturelle Genomforschung (POF4-312) |0 G:(DE-HGF)POF4-312 |c POF4-312 |f POF IV |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, , Journals: inrepo02.dkfz.de |
| 650 | _ | 2 | |a Humans |2 MeSH |
| 650 | _ | 2 | |a Immunotherapy |2 MeSH |
| 650 | _ | 2 | |a Digestive System Neoplasms: therapy |2 MeSH |
| 650 | _ | 2 | |a Digestive System Neoplasms: genetics |2 MeSH |
| 650 | _ | 2 | |a Digestive System Neoplasms: pathology |2 MeSH |
| 650 | _ | 2 | |a Digestive System Neoplasms: immunology |2 MeSH |
| 700 | 1 | _ | |a Betge, Johannes |0 P:(DE-He78)68cbca3e3973d332ccc4c6e31a76b10c |b 1 |e First author |u dkfz |
| 700 | 1 | _ | |a Schulte, Nadine |b 2 |
| 700 | 1 | _ | |a Dreikhausen, Lena |b 3 |
| 700 | 1 | _ | |a Hirth, Michael |b 4 |
| 700 | 1 | _ | |a Li, Moying |b 5 |
| 700 | 1 | _ | |a Weidner, Philip |b 6 |
| 700 | 1 | _ | |a Leipertz, Antonia |b 7 |
| 700 | 1 | _ | |a Teufel, Andreas |b 8 |
| 700 | 1 | _ | |a Ebert, Matthias P |b 9 |
| 773 | _ | _ | |a 10.1038/s41392-024-02097-4 |g Vol. 10, no. 1, p. 24 |0 PERI:(DE-600)2886872-9 |n 1 |p 24 |t Signal transduction and targeted therapy |v 10 |y 2025 |x 2095-9907 |
| 909 | C | O | |o oai:inrepo02.dkfz.de:297961 |p VDB |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 1 |6 P:(DE-He78)68cbca3e3973d332ccc4c6e31a76b10c |
| 913 | 1 | _ | |a DE-HGF |b Gesundheit |l Krebsforschung |1 G:(DE-HGF)POF4-310 |0 G:(DE-HGF)POF4-312 |3 G:(DE-HGF)POF4 |2 G:(DE-HGF)POF4-300 |4 G:(DE-HGF)POF |v Funktionelle und strukturelle Genomforschung |x 0 |
| 914 | 1 | _ | |y 2025 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0200 |2 StatID |b SCOPUS |d 2024-12-17 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline |d 2024-12-17 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0501 |2 StatID |b DOAJ Seal |d 2024-04-10T15:44:53Z |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0500 |2 StatID |b DOAJ |d 2024-04-10T15:44:53Z |
| 915 | _ | _ | |a Peer Review |0 StatID:(DE-HGF)0030 |2 StatID |b DOAJ : Anonymous peer review |d 2024-04-10T15:44:53Z |
| 915 | _ | _ | |a Creative Commons Attribution CC BY (No Version) |0 LIC:(DE-HGF)CCBYNV |2 V:(DE-HGF) |b DOAJ |d 2024-04-10T15:44:53Z |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0199 |2 StatID |b Clarivate Analytics Master Journal List |d 2024-12-17 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1050 |2 StatID |b BIOSIS Previews |d 2024-12-17 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0160 |2 StatID |b Essential Science Indicators |d 2024-12-17 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1190 |2 StatID |b Biological Abstracts |d 2024-12-17 |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0113 |2 StatID |b Science Citation Index Expanded |d 2024-12-17 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0150 |2 StatID |b Web of Science Core Collection |d 2024-12-17 |
| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b SIGNAL TRANSDUCT TAR : 2022 |d 2024-12-17 |
| 915 | _ | _ | |a IF >= 30 |0 StatID:(DE-HGF)9930 |2 StatID |b SIGNAL TRANSDUCT TAR : 2022 |d 2024-12-17 |
| 915 | _ | _ | |a Article Processing Charges |0 StatID:(DE-HGF)0561 |2 StatID |d 2024-12-17 |
| 915 | _ | _ | |a Fees |0 StatID:(DE-HGF)0700 |2 StatID |d 2024-12-17 |
| 920 | 1 | _ | |0 I:(DE-He78)B440-20160331 |k B440 |l NWG-KKE Translationale Gastrointestinale Onkologie und präklinische Modelle |x 0 |
| 920 | 0 | _ | |0 I:(DE-He78)B440-20160331 |k B440 |l NWG-KKE Translationale Gastrointestinale Onkologie und präklinische Modelle |x 0 |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a I:(DE-He78)B440-20160331 |
| 980 | _ | _ | |a UNRESTRICTED |
| Library | Collection | CLSMajor | CLSMinor | Language | Author |
|---|