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| 001 | 297967 | ||
| 005 | 20250119014841.0 | ||
| 024 | 7 | _ | |a 10.1038/s41467-025-55928-5 |2 doi |
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| 037 | _ | _ | |a DKFZ-2025-00144 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 500 |
| 100 | 1 | _ | |a Neugebauer, Eva |0 0009-0009-6298-5267 |b 0 |
| 245 | _ | _ | |a Herpesviruses mimic zygotic genome activation to promote viral replication. |
| 260 | _ | _ | |a [London] |c 2025 |b Springer Nature |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1737116681_18536 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
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| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Zygotic genome activation (ZGA) is crucial for maternal to zygotic transition at the 2-8-cell stage in order to overcome silencing of genes and enable transcription from the zygotic genome. In humans, ZGA is induced by DUX4, a pioneer factor that drives expression of downstream germline-specific genes and retroelements. Here we show that herpesviruses from all subfamilies, papillomaviruses and Merkel cell polyomavirus actively induce DUX4 expression to promote viral transcription and replication. Analysis of single-cell sequencing data sets from patients shows that viral DUX4 activation is of relevance in vivo. Herpes-simplex virus 1 (HSV-1) immediate early proteins directly induce expression of DUX4 and its target genes, which mimics zygotic genome activation. Upon HSV-1 infection, DUX4 directly binds to the viral genome and promotes viral transcription. DUX4 is functionally required for infection, since genetic depletion by CRISPR/Cas9 as well as degradation of DUX4 by nanobody constructs abrogates HSV-1 replication. Our results show that DNA viruses including herpesviruses mimic an embryonic-like transcriptional program that prevents epigenetic silencing of the viral genome and facilitates herpesviral gene expression. |
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| 650 | _ | 7 | |a Homeodomain Proteins |2 NLM Chemicals |
| 650 | _ | 2 | |a Virus Replication: genetics |2 MeSH |
| 650 | _ | 2 | |a Humans |2 MeSH |
| 650 | _ | 2 | |a Zygote: metabolism |2 MeSH |
| 650 | _ | 2 | |a Zygote: virology |2 MeSH |
| 650 | _ | 2 | |a Herpesvirus 1, Human: genetics |2 MeSH |
| 650 | _ | 2 | |a Herpesvirus 1, Human: physiology |2 MeSH |
| 650 | _ | 2 | |a Genome, Viral |2 MeSH |
| 650 | _ | 2 | |a Homeodomain Proteins: metabolism |2 MeSH |
| 650 | _ | 2 | |a Homeodomain Proteins: genetics |2 MeSH |
| 650 | _ | 2 | |a Herpesviridae: genetics |2 MeSH |
| 650 | _ | 2 | |a Herpesviridae: physiology |2 MeSH |
| 650 | _ | 2 | |a Gene Expression Regulation, Viral |2 MeSH |
| 650 | _ | 2 | |a Animals |2 MeSH |
| 650 | _ | 2 | |a HEK293 Cells |2 MeSH |
| 650 | _ | 2 | |a Merkel cell polyomavirus: genetics |2 MeSH |
| 700 | 1 | _ | |a Walter, Stephanie |b 1 |
| 700 | 1 | _ | |a Tan, Jiang |0 0009-0005-8827-3533 |b 2 |
| 700 | 1 | _ | |a Drayman, Nir |b 3 |
| 700 | 1 | _ | |a Franke, Vedran |0 0000-0003-3606-6792 |b 4 |
| 700 | 1 | _ | |a van Gent, Michiel |0 0000-0003-3798-5360 |b 5 |
| 700 | 1 | _ | |a Pennisi, Sandra |b 6 |
| 700 | 1 | _ | |a Veratti, Pia |b 7 |
| 700 | 1 | _ | |a Stein, Karla S |b 8 |
| 700 | 1 | _ | |a Welker, Isabelle |0 0009-0007-9507-3622 |b 9 |
| 700 | 1 | _ | |a Tay, Savaş |0 0000-0002-1912-6020 |b 10 |
| 700 | 1 | _ | |a Verjans, Georges M G M |0 0000-0002-2465-2674 |b 11 |
| 700 | 1 | _ | |a Timmers, Hermanus Theodorus Marcus |0 P:(DE-He78)a77f61c7d4ca6aa1f9adc620eed66f3d |b 12 |u dkfz |
| 700 | 1 | _ | |a Akalin, Altuna |0 0000-0002-0468-0117 |b 13 |
| 700 | 1 | _ | |a Landthaler, Markus |0 0000-0002-1075-8734 |b 14 |
| 700 | 1 | _ | |a Ensser, Armin |0 0000-0001-8873-3863 |b 15 |
| 700 | 1 | _ | |a Wyler, Emanuel |0 0000-0002-9884-1806 |b 16 |
| 700 | 1 | _ | |a Full, Florian |0 0000-0003-1900-5891 |b 17 |
| 773 | _ | _ | |a 10.1038/s41467-025-55928-5 |g Vol. 16, no. 1, p. 710 |0 PERI:(DE-600)2553671-0 |n 1 |p 710 |t Nature Communications |v 16 |y 2025 |x 2041-1723 |
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