%0 Journal Article
%A Cocciardi, Sibylle
%A Saadati, Maral
%A Weiß, Nina
%A Späth, Daniela
%A Kapp-Schwoerer, Silke
%A Schneider, Isabelle
%A Meid, Annika
%A Gaidzik, Verena I
%A Skambraks, Sabrina
%A Fiedler, Walter
%A Kühn, Michael W M
%A Germing, Ulrich
%A Mayer, Karin T
%A Lübbert, Michael
%A Papaemmanuil, Elli
%A Thol, Felicitas
%A Heuser, Michael
%A Ganser, Arnold
%A Bullinger, Lars
%A Benner, Axel
%A Döhner, Hartmut
%A Döhner, Konstanze
%T Impact of myelodysplasia-related and additional gene mutations in intensively treated patients with NPM1-mutated AML.
%J HemaSphere
%V 9
%N 1
%@ 2572-9241
%C Hoboken
%I John Wiley & Sons Ltd.
%M DKFZ-2025-00152
%P e70060
%D 2025
%X This study aimed to evaluate the impact of the myelodysplasia-related gene (MRG) as well as additional gene mutations on outcomes in intensively treated patients with NPM1-mutated (NPM1 mut) AML. Targeted DNA sequencing of 263 genes was performed in 568 NPM1 mut AML patients (median age: 59 years) entered into the prospective AMLSG 09-09 treatment trial. Most commonly co-mutated genes were DNMT3A (49.8
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:39816531
%2 pmc:PMC11733593
%R 10.1002/hem3.70060
%U https://inrepo02.dkfz.de/record/297977