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000297993 1001_ $$0P:(DE-He78)66709673985c9dca243b45cfbe991001$$aHaggenmüller, Sarah$$b0$$eFirst author$$udkfz
000297993 245__ $$aDiscordance, accuracy and reproducibility study of pathologists' diagnosis of melanoma and melanocytic tumors.
000297993 260__ $$a[London]$$bSpringer Nature$$c2025
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000297993 520__ $$aAccurate melanoma diagnosis is crucial for patient outcomes and reliability of AI diagnostic tools. We assess interrater variability among eight expert pathologists reviewing histopathological images and clinical metadata of 792 melanoma-suspicious lesions prospectively collected at eight German hospitals. Moreover, we provide access to the largest panel-validated dataset featuring dermoscopic and histopathological images with metadata. Complete agreement is achieved in 53.5% of cases (424/792), and a majority vote ( ≥ five pathologists) in 90.9% (720/792). Considerable discordance is observed for non-invasive melanomas (complete agreement in only 10/73 cases). The expert panel disagrees with the local pathologists' and dermatologists' diagnoses in 14.9% and 33.5% of cases, respectively. This variability highlights the diagnostic challenges of early-stage melanomas and the need to reconsider how ground truth is established in routine care and AI research. Including at least two pathologists or virtual panels may contribute to more consistent diagnostic results.
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000297993 650_2 $$2MeSH$$aHumans
000297993 650_2 $$2MeSH$$aMelanoma: diagnosis
000297993 650_2 $$2MeSH$$aMelanoma: pathology
000297993 650_2 $$2MeSH$$aMelanoma: diagnostic imaging
000297993 650_2 $$2MeSH$$aPathologists
000297993 650_2 $$2MeSH$$aReproducibility of Results
000297993 650_2 $$2MeSH$$aSkin Neoplasms: pathology
000297993 650_2 $$2MeSH$$aSkin Neoplasms: diagnosis
000297993 650_2 $$2MeSH$$aObserver Variation
000297993 650_2 $$2MeSH$$aFemale
000297993 650_2 $$2MeSH$$aMale
000297993 650_2 $$2MeSH$$aMiddle Aged
000297993 650_2 $$2MeSH$$aAdult
000297993 650_2 $$2MeSH$$aDermoscopy: methods
000297993 650_2 $$2MeSH$$aGermany
000297993 650_2 $$2MeSH$$aAged
000297993 650_2 $$2MeSH$$aProspective Studies
000297993 7001_ $$0P:(DE-He78)3c4243de81f11e32405a8ad3bd617e2f$$aWies, Christoph$$b1$$udkfz
000297993 7001_ $$0P:(DE-He78)6ff1d8cd02e50566a935419daf3d6a93$$aAbels, Julia$$b2$$udkfz
000297993 7001_ $$0P:(DE-He78)3bd296f65df45e39a49f2b4a3479aa6b$$aWinterstein, Jana$$b3$$udkfz
000297993 7001_ $$0P:(DE-He78)c61c1fde6d25ab912db161ff81097a3e$$aHeinlein, Lukas$$b4$$udkfz
000297993 7001_ $$0P:(DE-He78)c610227e901cd260fdb2f026b54823f4$$aNogueira Garcia, Carina$$b5$$udkfz
000297993 7001_ $$0P:(DE-He78)a229f7724466e7efadf4a1ace1ff8af3$$aUtikal, Jochen$$b6$$udkfz
000297993 7001_ $$0P:(DE-He78)843d6e8cab17c2120fe6638b22e674e2$$aWohlfeil, Sebastian$$b7$$udkfz
000297993 7001_ $$00000-0003-4340-9706$$aMeier, Friedegund$$b8
000297993 7001_ $$aHobelsberger, Sarah$$b9
000297993 7001_ $$00000-0002-2164-4644$$aGellrich, Frank F$$b10
000297993 7001_ $$aSergon, Mildred$$b11
000297993 7001_ $$aHauschild, Axel$$b12
000297993 7001_ $$00000-0002-4629-1486$$aFrench, Lars E$$b13
000297993 7001_ $$aHeinzerling, Lucie$$b14
000297993 7001_ $$aSchlager, Justin G$$b15
000297993 7001_ $$00000-0002-5526-7517$$aGhoreschi, Kamran$$b16
000297993 7001_ $$00000-0002-1663-8098$$aSchlaak, Max$$b17
000297993 7001_ $$aHilke, Franz J$$b18
000297993 7001_ $$aPoch, Gabriela$$b19
000297993 7001_ $$aKorsing, Sören$$b20
000297993 7001_ $$aSarfert, Cosimo$$b21
000297993 7001_ $$00000-0003-0229-8931$$aBerking, Carola$$b22
000297993 7001_ $$00000-0003-4603-1825$$aHeppt, Markus V$$b23
000297993 7001_ $$00000-0001-7136-6489$$aErdmann, Michael$$b24
000297993 7001_ $$aHaferkamp, Sebastian$$b25
000297993 7001_ $$aDrexler, Konstantin$$b26
000297993 7001_ $$00000-0003-3524-7858$$aSchadendorf, Dirk$$b27
000297993 7001_ $$00000-0002-3684-3523$$aSondermann, Wiebke$$b28
000297993 7001_ $$00000-0001-7095-9848$$aGoebeler, Matthias$$b29
000297993 7001_ $$00000-0001-8859-4103$$aSchilling, Bastian$$b30
000297993 7001_ $$aKather, Jakob Nikolas$$b31
000297993 7001_ $$0P:(DE-He78)f0144d171d26dbedb67c9db1df35629d$$aFröhling, Stefan$$b32
000297993 7001_ $$aLlamas-Velasco, Mar$$b33
000297993 7001_ $$aRequena, Luis C$$b34
000297993 7001_ $$00000-0003-0727-4015$$aFerrara, Gerardo$$b35
000297993 7001_ $$00000-0002-2366-7110$$aFernandez-Figueras, Maite$$b36
000297993 7001_ $$aFraitag, Sylvie$$b37
000297993 7001_ $$aMüller, Cornelia S L$$b38
000297993 7001_ $$aStarz, Hans$$b39
000297993 7001_ $$aKutzner, Heinz$$b40
000297993 7001_ $$aBarnhill, Raymond$$b41
000297993 7001_ $$aCarr, Richard$$b42
000297993 7001_ $$aResnik, Kenneth S$$b43
000297993 7001_ $$00000-0002-5600-0195$$aBraun, Stephan Alexander$$b44
000297993 7001_ $$0P:(DE-He78)457c042884c901eb0a02c18bb1d30103$$aHolland-Letz, Tim$$b45$$udkfz
000297993 7001_ $$0P:(DE-He78)1e33961c8780aca9b76d776d1fdc1ebb$$aBrinker, Titus$$b46$$eLast author$$udkfz
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