TY  - JOUR
AU  - Lohner, Valerie
AU  - Perna, Laura
AU  - Schöttker, Ben
AU  - Perneczky, Robert
AU  - Brenner, Hermann
AU  - Mons, Ute
TI  - Associations of blood-based biomarkers of neurodegenerative diseases with mortality, cardio- and cerebrovascular events in persons with chronic coronary syndrome.
JO  - Experimental gerontology
VL  - 200
SN  - 0531-5565
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - DKFZ-2025-00170
SP  - 112684
PY  - 2025
N1  - #LA:C120# / Volume 200, February 2025, 112684
AB  - In light of growing evidence highlighting interactions between cardiac and brain health, we investigated associations of biomarkers of neurodegenerative diseases with adverse outcomes (all-cause and cardiovascular mortality, major cardiovascular events, and stroke) in persons with chronic coronary syndrome (CCS).We used data from a cohort of persons with CCS for whom major adverse events were recorded over a follow-up of 20 years. We measured biomarkers of neurodegenerative diseases in baseline blood samples, using the Single-Molecule Array Technology on a HD-1 Analyzer. These include biomarkers of neuronal (neurofilament light chain (NfL) (n = 379)) and glial neurodegeneration (glial fibrillary acidic protein (GFAP) (n = 379)), and Alzheimer's disease pathology (phosphorylated tau181 (n = 379), total tau (n = 377), and amyloid β (Aβ40, Aβ42, Aβ42/Aβ40) (n = 377)). We applied Cox-proportional hazards models to evaluate associations of these biomarkers with adverse outcomes, adjusting for covariates and exploring interactions with apolipoprotein E (ApoE) ε4 genotype.Participants with higher NfL levels had increased rates of all-cause and cardiovascular mortality (Hazard ratio per increase by one standard deviation (95 
KW  - Blood-based biomarkers of neurodegenerative diseases (Other)
KW  - Cerebrovascular events (Other)
KW  - Chronic coronary syndrome (Other)
KW  - Coronary heart disease (Other)
KW  - Epidemiology (Other)
KW  - Major cardiovascular events (Other)
KW  - Mortality (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:39824235
DO  - DOI:10.1016/j.exger.2025.112684
UR  - https://inrepo02.dkfz.de/record/297995
ER  -