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037 _ _ |a DKFZ-2025-00187
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Valdés-Mas, Rafael
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245 _ _ |a Metagenome-informed metaproteomics of the human gut microbiome, host, and dietary exposome uncovers signatures of health and inflammatory bowel disease.
260 _ _ |a [Cambridge, Mass.]
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500 _ _ |a #LA:D480# / 2025 Feb 20;188(4):1062-1083.e36
520 _ _ |a Host-microbiome-dietary interactions play crucial roles in regulating human health, yet their direct functional assessment remains challenging. We adopted metagenome-informed metaproteomics (MIM), in mice and humans, to non-invasively explore species-level microbiome-host interactions during commensal and pathogen colonization, nutritional modification, and antibiotic-induced perturbation. Simultaneously, fecal MIM accurately characterized the nutritional exposure landscape in multiple clinical and dietary contexts. Implementation of MIM in murine auto-inflammation and in human inflammatory bowel disease (IBD) characterized a 'compositional dysbiosis' and a concomitant species-specific 'functional dysbiosis' driven by suppressed commensal responses to inflammatory host signals. Microbiome transfers unraveled early-onset kinetics of these host-commensal cross-responsive patterns, while predictive analyses identified candidate fecal host-microbiome IBD biomarker protein pairs outperforming S100A8/S100A9 (calprotectin). Importantly, a simultaneous fecal nutritional MIM assessment enabled the determination of IBD-related consumption patterns, dietary treatment compliance, and small intestinal digestive aberrations. Collectively, a parallelized dietary-bacterial-host MIM assessment functionally uncovers trans-kingdom interactomes shaping gastrointestinal ecology while offering personalized diagnostic and therapeutic insights into microbiome-associated disease.
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650 _ 7 |a biomarker
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650 _ 7 |a diet
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650 _ 7 |a inflammatory bowel disease
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650 _ 7 |a metagenome-informed metaproteomics
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650 _ 7 |a microbiome
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700 1 _ |a Leshem, Avner
|b 1
700 1 _ |a Zheng, Danping
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700 1 _ |a Cohen, Yotam
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700 1 _ |a Kern, Lara
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700 1 _ |a Zmora, Niv
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700 1 _ |a He, Yiming
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700 1 _ |a Katina, Corine
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700 1 _ |a Eliyahu-Miller, Shimrit
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700 1 _ |a Yosef-Hevroni, Tal
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700 1 _ |a Richman, Liron
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700 1 _ |a Raykhel, Barbara
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700 1 _ |a Allswang, Shira
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700 1 _ |a Better, Reut
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700 1 _ |a Shmueli, Merav
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700 1 _ |a Saftien, Aurelia
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700 1 _ |a Cullin, Nyssa
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700 1 _ |a Slamovitz, Fernando
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700 1 _ |a Ciocan, Dragos
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700 1 _ |a Ouyang, Kyanna S
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700 1 _ |a Mor, Uria
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700 1 _ |a Dori-Bachash, Mally
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700 1 _ |a Molina, Shahar
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700 1 _ |a Levin, Yishai
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700 1 _ |a Atarashi, Koji
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700 1 _ |a Jona, Ghil
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700 1 _ |a Puschhof, Jens
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700 1 _ |a Harmelin, Alon
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700 1 _ |a Stettner, Noa
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700 1 _ |a Chen, Minhu
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700 1 _ |a Suez, Jotham
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700 1 _ |a Honda, Kenya
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700 1 _ |a Lieb, Wolfgang
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700 1 _ |a Bang, Corinna
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700 1 _ |a Kori, Michal
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700 1 _ |a Maharshak, Nitsan
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700 1 _ |a Merbl, Yifat
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700 1 _ |a Shibolet, Oren
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700 1 _ |a Halpern, Zamir
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700 1 _ |a Shouval, Dror S
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700 1 _ |a Shamir, Raanan
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700 1 _ |a Franke, Andre
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700 1 _ |a Abdeen, Suhaib K
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700 1 _ |a Shapiro, Hagit
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700 1 _ |a Savidor, Alon
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700 1 _ |a Elinav, Eran
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