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000298213 1001_ $$0P:(DE-HGF)0$$aSumer, Oyku Ece$$b0$$eFirst author
000298213 245__ $$aSelective arm-usage of pre-miR-1307 dysregulates angiogenesis and affects breast cancer aggressiveness.
000298213 260__ $$aHeidelberg$$bSpringer$$c2025
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000298213 520__ $$aBreast cancer is the leading cause of cancer-related mortality in women. Deregulation of miRNAs is frequently observed in breast cancer and affects tumor biology. A pre-miRNA, such as pre-miR-1307, gives rise to several mature miRNA molecules with distinct functions. However, the impact of global deregulation of pre-miR-1307 and its individual mature miRNAs in breast cancer has not been investigated in breast cancer, yet.Here, we found significant upregulation of three mature miRNA species derived from pre-miR-1307 in human breast cancer tissue. Surprisingly, the overexpression of pre-miR-1307 in breast cancer cell lines resulted in reduced xenograft growth and impaired angiogenesis. Mechanistically, overexpression of miR-1307-5p altered the secretome of breast cancer cells and reduced endothelial cell sprouting. Consistently, expression of miR-1307-5p was inversely correlated with endothelial cell fractions in human breast tumors pointing at an anti-angiogenic role of miR-1307-5p. Importantly, the arm usage of miR-1307 and other miRNAs was highly correlated, which suggests an undefined common regulatory mechanism.In summary, miR-1307-5p reduces angiogenesis in breast cancer, thereby antagonizing the oncogenic effects of miR-1307-3p. Our results emphasize the importance of future research on the regulation of miRNA arm selection in cancer. The underlying mechanisms might inspire new therapeutic strategies aimed at shifting the balance towards tumor-suppressive miRNA species.
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000298213 650_7 $$2Other$$aAngiogenesis
000298213 650_7 $$2Other$$aBreast cancer
000298213 650_7 $$2Other$$aIsomiRs
000298213 650_7 $$2Other$$aMetastasis
000298213 650_7 $$2Other$$aSelective arm-usage of miRNA
000298213 650_7 $$2Other$$amiR-1307
000298213 650_7 $$2Other$$amiRNA arm switch
000298213 650_7 $$2Other$$amiRNAs
000298213 650_7 $$2NLM Chemicals$$aMicroRNAs
000298213 650_7 $$2NLM Chemicals$$aMIRN1307 microRNA, human
000298213 650_2 $$2MeSH$$aMicroRNAs: genetics
000298213 650_2 $$2MeSH$$aMicroRNAs: metabolism
000298213 650_2 $$2MeSH$$aBreast Neoplasms: genetics
000298213 650_2 $$2MeSH$$aBreast Neoplasms: pathology
000298213 650_2 $$2MeSH$$aHumans
000298213 650_2 $$2MeSH$$aFemale
000298213 650_2 $$2MeSH$$aNeovascularization, Pathologic: genetics
000298213 650_2 $$2MeSH$$aAnimals
000298213 650_2 $$2MeSH$$aCell Line, Tumor
000298213 650_2 $$2MeSH$$aMice
000298213 650_2 $$2MeSH$$aGene Expression Regulation, Neoplastic
000298213 650_2 $$2MeSH$$aAngiogenesis
000298213 7001_ $$0P:(DE-He78)94f8b1423d5cbb067c5cda38dd1d0f9f$$aSchelzig, Korbinian$$b1$$eFirst author
000298213 7001_ $$0P:(DE-He78)a6ddb0231bceb756854b9eae81bd15b2$$aJung, Janine$$b2
000298213 7001_ $$0P:(DE-He78)54c23e22f76a7925b5ffeeae323bb5c9$$aLi, Xiaoya$$b3
000298213 7001_ $$0P:(DE-He78)da99acd848dce82df9af27360305a61f$$aMoros, Janina$$b4
000298213 7001_ $$0P:(DE-He78)c0f06b8e8c4978a970ffe6531ded37b2$$aSchwarzmüller, Luisa$$b5$$udkfz
000298213 7001_ $$0P:(DE-He78)c77abdcfce18b6eb0f9943c96a9076fa$$aSen, Ezgi$$b6$$udkfz
000298213 7001_ $$0P:(DE-He78)5e988283bb9620f86c640513ed6347d6$$aKarolus, Sabine$$b7$$udkfz
000298213 7001_ $$0P:(DE-He78)4bc62c4328ee88a188151ce56b0f9f50$$aWörner, Angelika$$b8$$udkfz
000298213 7001_ $$0P:(DE-HGF)0$$ade Melo Costa, Verônica Rodrigues$$b9
000298213 7001_ $$aNataraj, Nishanth Belugali$$b10
000298213 7001_ $$0P:(DE-He78)f2f38d242b5d8cb3903e0ed098e8b554$$aVlachavas, Efstathios-Iason$$b11$$udkfz
000298213 7001_ $$0P:(DE-He78)3c4679d03b730156fae20c4948722efe$$aGerhäuser, Clarissa$$b12$$udkfz
000298213 7001_ $$0P:(DE-He78)799d978330dff449f8244947929a4518$$aMüller-Decker, Karin$$b13
000298213 7001_ $$0P:(DE-He78)daaed5a5b968028e6e95d273150d5ab1$$aHelm, Dominic$$b14$$udkfz
000298213 7001_ $$aYarden, Yosef$$b15
000298213 7001_ $$0P:(DE-He78)b48bfd64120195b64b5f11d32ce5ed5e$$aMichels, Birgitta Elisabeth$$b16$$udkfz
000298213 7001_ $$0P:(DE-He78)a2dde36c70db0249408e1d88843d17a9$$aKörner, Cindy$$b17$$eLast author$$udkfz
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